单位拷贝质粒的分配函数可在低拷贝数时稳定质粒pBR322的维持。
Partition functions of unit-copy plasmids can stabilize the maintenance of plasmid pBR322 at low copy number.
作者信息
Austin S, Friedman S, Ludtke D
出版信息
J Bacteriol. 1986 Nov;168(2):1010-3. doi: 10.1128/jb.168.2.1010-1013.1986.
Abstract
The maintenance of plasmid pBR322 is highly unstable in a polA12 strain of Escherichia coli at 29 degrees C due to severely reduced copy number. Under these conditions, introduction of the par (partition) locus of plasmid P1 or the par (sop) region of F into pBR322 stabilizes it. A region with similar activity was detected in the P7 plasmid. The activity of the P1 par locus was dependent on the P1 parA gene product and was sensitive to par-specified incompatibility.
摘要
由于拷贝数严重减少，质粒pBR322在大肠杆菌的polA12菌株中于29℃下的维持高度不稳定。在这些条件下，将质粒P1的par（分配）位点或F的par（sop）区域引入pBR322可使其稳定。在P7质粒中检测到具有类似活性的区域。P1 par位点的活性依赖于P1 parA基因产物，并且对par指定的不相容性敏感。
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