TRPM2 在急性肾损伤和肾脏纤维化中作用较小。
TRPM2 Plays a Minor Role in AKI and Kidney Fibrosis.
机构信息
Division of Nephrology and Endocrinology, The University of Tokyo, Tokyo, Japan.
Research and Development, Bayer AG, Pharmaceuticals, Wuppertal, Germany.
出版信息
Kidney360. 2021 Oct 22;3(1):153-157. doi: 10.34067/KID.0005492021. eCollection 2022 Jan 27.
Abstract
TRPM2 is a Ca2-permeable cationic channel and serves as an oxidative stress sensor.TRPM2 deletion was harmful in renal ischemia-reperfusion injury, whereas TRPM2 deletion mitigated kidney fibrosis.Our findings suggest the role of TRPM2 in kidney diseases is context dependent.
摘要
TRPM2 是一种 Ca2+渗透性阳离子通道，可作为氧化应激传感器。TRPM2 缺失在肾缺血再灌注损伤中是有害的，而 TRPM2 缺失则减轻了肾纤维化。我们的研究结果表明，TRPM2 在肾脏疾病中的作用是有条件的。
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