Anesthesiology Department, Handan Central Hospital, Handan 056001, China.
J Healthc Eng. 2022 Mar 25;2022:6971092. doi: 10.1155/2022/6971092. eCollection 2022.
In order to investigate the effects of sevoflurane on the serum stress index level and prognosis of patients with hypertensive cerebral hemorrhage (HICH) during small bone window microsurgery, a total of 102 HICH patients are selected for analysis. MAP values in both groups decreased significantly at T1 and T2 ( < 0.05), and the changes in MAP and HR indexes in the sevoflurane combined group were more stable than those in the control group. The time of postoperative awakening in the sevoflurane combined group decreases significantly than the control group ( < 0.001). The levels of T-AOC and GSH-Px in both groups increase significantly after operation, and those in the sevoflurane combined group increase significantly than the control group ( < 0.001). The levels of MDA and 8-OHDG in the sevoflurane combined group decrease significantly than the control group after operation ( < 0.05). Spearman correlation coefficient analysis shows that the levels of T-AOC and GSH-Px are negatively correlated with the prognosis of HICH patients, while MDA and 8-OHDG are positively correlated with the prognosis of HICH patients ( < 0.001). Sevoflurane interventional anesthesia has a high anesthetic effect in small bone window microsurgery, which has positive effects on controlling blood pressure of HICH patients, shortening postoperative recovery time and improving patients' stress response and neurological function. This paper conducts an in-depth analysis of the prognosis of HICH patients, indicating that the prognosis of HICH patients is closely related to their serum stress indicators T-AOC, GSH-Px, MDA, and 8-OHDG, providing a new direction for follow-up clinical diagnosis and treatment of HICH patients and accurate prognosis assessment.
为了探讨七氟醚对高血压脑出血（HICH）患者小骨窗微创手术中血清应激指标水平及预后的影响，分析了 102 例 HICH 患者。两组患者 T1 和 T2 时 MAP 值均明显下降（<0.05），七氟醚复合组 MAP 和 HR 指标变化较对照组更稳定。七氟醚复合组术后觉醒时间明显短于对照组（<0.001）。两组患者术后 T-AOC 和 GSH-Px 水平均明显升高，七氟醚复合组升高幅度明显大于对照组（<0.001）。七氟醚复合组术后 MDA 和 8-OHDG 水平明显低于对照组（<0.05）。Spearman 相关系数分析显示，T-AOC 和 GSH-Px 水平与 HICH 患者的预后呈负相关，而 MDA 和 8-OHDG 水平与 HICH 患者的预后呈正相关（<0.001）。七氟醚介入麻醉在小骨窗微创手术中具有较高的麻醉效果，对控制 HICH 患者血压、缩短术后恢复时间、改善患者应激反应和神经功能具有积极作用。本文对 HICH 患者的预后进行了深入分析，表明 HICH 患者的预后与其血清应激指标 T-AOC、GSH-Px、MDA 和 8-OHDG 密切相关，为 HICH 患者的后续临床诊断和治疗及准确预后评估提供了新的方向。
