The Psychological Hospital, Qingdao Mental Health Center, Qingdao 266034, Shandong Province, China.
Qingdao University, 308 Ningxia Road, Qingdao 266071, Shandong Province, China.
J Healthc Eng. 2022 Mar 25;2022:9148650. doi: 10.1155/2022/9148650. eCollection 2022.
To explore the effect of resveratrol (RES) combined with donepezil hydrochloride on inflammatory factor level and cognitive function level of patients with Alzheimer's disease (AD).
A total of 90 AD patients treated in our hospital from June 2019 to June 2020 were selected as the study objects and divided into the control group (CG) and experimental group (EG) by the randomized and double-blind method, with 45 cases each. Patients in CG received donepezil hydrochloride treatment, and on this basis, those in EG received additional RES treatment, so as to compare the clinical indicators between the two groups.
Compared with CG after treatment, EG obtained significantly higher good rate, MMSE score, and FIM score ( < 0.05) and obviously lower clinical indicators and ADAS-cog score ( < 0.001), and between CG and EG, no obvious difference in total incidence rate of adverse reactions was observed after treatment ( > 0.05).
Combining RES with donepezil hydrochloride has significant clinical efficacy in treating AD, which can effectively improve patients' inflammatory factor indicators, promote their cognitive function, and facilitate patient prognosis.
探讨白藜芦醇（RES）联合盐酸多奈哌齐对阿尔茨海默病（AD）患者炎症因子水平及认知功能水平的影响。
选取 2019 年 6 月至 2020 年 6 月在我院治疗的 90 例 AD 患者作为研究对象，采用随机、双盲法将其分为对照组（CG）和实验组（EG），每组 45 例。CG 患者接受盐酸多奈哌齐治疗，EG 患者在此基础上联合 RES 治疗，对比两组患者的临床指标。
与 CG 组治疗后相比，EG 组的总有效率、MMSE 评分和 FIM 评分更高（<0.05），临床指标及 ADAS-cog 评分更低（<0.001），但治疗后不良反应总发生率两组间差异无统计学意义（>0.05）。
RES 联合盐酸多奈哌齐治疗 AD 具有显著的临床疗效，可有效改善患者的炎症因子指标，促进其认知功能恢复，利于患者预后。
