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显微镜图像下儿童急性心理应激与行为应激对免疫功能影响的 Meta 分析。

Meta-Analysis of Children's Acute Psychological Stress and Action Stress on Immune Function under Microscope Images.

机构信息

School of Medicine, Lishui University, Lishui 323000, Zhejiang, China.

School of Basic Medicine, Xiangnan University, Chenzhou 423000, Hunan, China.

出版信息

J Healthc Eng. 2022 Mar 23;2022:6549805. doi: 10.1155/2022/6549805. eCollection 2022.

Abstract

The immune system is a complex system, mainly including immune cells and immune organs. When the human body is invaded by foreign substances, the immune system will play a role in resisting the attack of harmful substances and pure necrotic cells, which is the defense structure of the body. The purpose of this study was to analyze children's acute psychological stress and action stress, and judge the adverse effects on immune function. Through the stress experiment of rats, three experimental groups were set up, which were placebo control group, placebo stress group, and drug stress group. The experiments include material-level test, sugar preference test, body weight test, and lymphocyte test. The experimental data show that stress reaction not only causes negative emotions, but also reduces weight gain by about 5%, and sugar preference decreases by about 40% compared with the normal group. There was no significant difference in the number of granulocytes and intermediate cells in the blood, but the number of lymphocytes increased from 2.49 × 10/L to 5.03 × 10/L. It shows that acute psychological stress has an inhibitory effect on the immune function of the body; not only suitable load exercise can improve the immune function of the body but also the mechanism may be that moderate load exercise makes the rat axis has better adaptability, and improves hormones, cytokines, and cytokines. The secretion of neurotransmitters can maintain the stability of the body's immune function.

摘要

免疫系统是一个复杂的系统,主要包括免疫细胞和免疫器官。当人体受到外来物质的侵袭时,免疫系统会发挥作用,抵抗有害物质和纯坏死细胞的攻击,这是身体的防御结构。本研究旨在分析儿童急性心理应激和动作应激,并判断对免疫功能的不良影响。通过对大鼠的应激实验,设置了安慰剂对照组、安慰剂应激组和药物应激组三个实验组。实验包括物质水平测试、糖偏好测试、体重测试和淋巴细胞测试。实验数据表明,应激反应不仅会引起负面情绪,还会使体重增加减少约 5%,与正常组相比,糖偏好减少约 40%。血液中粒细胞和中间细胞的数量没有明显差异,但淋巴细胞的数量从 2.49×10/L 增加到 5.03×10/L。这表明急性心理应激对机体的免疫功能有抑制作用;不仅适宜的负荷运动可以提高机体的免疫功能,而且其机制可能是适度的负荷运动使大鼠轴具有更好的适应性,提高了激素、细胞因子和神经递质的分泌,从而维持了机体免疫功能的稳定性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a817/8967515/6de2718db698/JHE2022-6549805.001.jpg

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