Lavarra Francesco, Tarantini Giuseppe, Sala Davide, Sirbu Vasile
Cardiovascular Department, Jilin Heart Hospital, Changchun, China.
Interventional Cardiology Unit, Department of Cardiac, Thoracic and Vascular Sciences, University of Padua Medical School, Padua, Italy.
Front Cardiovasc Med. 2022 Mar 15;9:861129. doi: 10.3389/fcvm.2022.861129. eCollection 2022.
The aim of this study was to explore the potential intraprocedural benefits of the Proximal Side Optimization (PSO) technique by Optical Coherence Tomography (OCT).
A case series of 10 consecutive true bifurcation lesions, with severe long pathology of long side branch (SB), were randomly assigned to be treated by standard DK Crush procedure (non-PSO group) as compared to DK Crush in PSO modification (PSO group). The data from OCT investigation before crushing of the SB Drug-Eluting Stent (DES), after crushing, after first kissing balloon inflation (KBI), and after final angiography were compared between the two groups (Public trials registry ISRCTN23355755).
All 10 cases were successfully treated by the assigned technique. The two groups were similar in terms of indications for the procedure, bifurcation angle, and stent dimensions. As compared to the non-PSO, the PSO group showed larger proximal SB stent areas (5.8 ± 1.8 vs. 4.5 ± 0.5 mm; = 0.02), the larger delta between distal and proximal stent areas before crush (1.5 ± 0.7 vs. 0.6 ± 0.5 mm; = 0.004), and the larger Space of Optimal Wiring (SOW) after Crush (5.3 ± 1.8 vs. 2.5 ± 1.1 mm; = 0.02). The gaps in scaffolding within the ostial segment of the Side Branch DES were found in two patients from the non-PSO group.
The DK Crush in PSO modification results in larger SB DES and SOW areas with better apposition to the vessel wall. As result, the SB DES acquires a funnel shape, which reduces the risk of passage outside the SB stent struts during re-wiring, thus, allowing predictable and secure results.
本研究旨在探讨光学相干断层扫描(OCT)引导下近端边支优化(PSO)技术在手术过程中的潜在益处。
连续选取10例伴有长分支严重病变的真性分叉病变患者,随机分为标准DK Crush术治疗组(非PSO组)和PSO改良的DK Crush术治疗组(PSO组)。比较两组在边支药物洗脱支架(DES)挤压前、挤压后、首次球囊对吻扩张(KBI)后及最终血管造影后的OCT检查数据(公共试验注册编号ISRCTN23355755)。
所有10例患者均成功接受了指定技术治疗。两组在手术指征、分叉角度和支架尺寸方面相似。与非PSO组相比,PSO组边支近端支架面积更大(5.8±1.8 vs. 4.5±0.5 mm²;P = 0.02),挤压前远端和近端支架面积差更大(1.5±0.7 vs. 0.6±0.5 mm²;P = 0.004),挤压后最佳导丝置入空间(SOW)更大(5.3±1.8 vs. 2.5±1.1 mm²;P = 0.02)。非PSO组有2例患者边支DES开口段存在支架网眼间隙。
PSO改良的DK Crush术可使边支DES和SOW面积更大,与血管壁贴靠更好。结果,边支DES呈漏斗状,降低了重新导丝操作过程中边支支架小梁外通过的风险,从而获得可预测且安全的结果。