L38菌株和MASCC - 0025对磺胺二甲氧嘧啶的代谢降解机制
Metabolic Mechanism of Sulfadimethoxine Biodegradation by sp. L38 and MASCC-0025.
作者信息
Li Bing, Wu Di, Li Yan, Shi Yan, Wang Chenlin, Sun Jiasi, Song Chunfeng
机构信息
Tianjin Academy of Agricultural Sciences, The Institute of Agriculture Resources and Environmental Sciences, Tianjin, China.
Tianjin Key Laboratory of Indoor Air Environmental Quality Control, School of Environmental Science and Engineering, Tianjin University, Tianjin, China.
出版信息
Front Microbiol. 2022 Mar 18;13:840562. doi: 10.3389/fmicb.2022.840562. eCollection 2022.
Antibiotic resistance is one of the most important environmental challenges. Microalgae has been considered as a promising green media for environmental purification. In this work, sulfadimethoxine (SDM) biodegradation potential of sp. L38 and MASCC-0025 is investigated. Experimental results indicated that the tested freshwater and marine microalgae strains presented stress response to SDM addition. For sp. L38, it has a good adaptability to SDM condition antioxidant enzyme secretion (SOD, MDA, and CAT up to 23.27 U/mg, 21.99 μmol/g, and 0.31 nmol/min/mg) with removal rate around 88%. MASCC-0025 exhibited 100% removal of 0.5 mg/L SDM. With increasing salinity (adding a certain amount of NaCl) of cultivation media, the removal rate of SDM by microalgae increased. Although its adaptive process was slower than sp. L38, the salinity advantage would facilitate enzyme accumulation. It indicated that microalgae could be used to remove SDM from freshwater and marine environment suitable microalgae strain screening.
抗生素耐药性是最重要的环境挑战之一。微藻被认为是一种有前途的用于环境净化的绿色介质。在这项工作中，研究了L38菌株和MASCC - 0025对磺胺二甲氧嘧啶（SDM）的生物降解潜力。实验结果表明，所测试的淡水和海洋微藻菌株对添加的SDM呈现应激反应。对于L38菌株，它对SDM条件具有良好的适应性，抗氧化酶分泌（超氧化物歧化酶、丙二醛和过氧化氢酶分别高达23.27 U/mg、21.99 μmol/g和0.31 nmol/min/mg），去除率约为88%。MASCC - 0025对0.5 mg/L的SDM去除率达100%。随着培养基盐度增加（添加一定量的氯化钠），微藻对SDM的去除率提高。尽管其适应过程比L38菌株慢，但盐度优势有利于酶的积累。这表明通过筛选合适的微藻菌株，微藻可用于从淡水和海洋环境中去除SDM。
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