Slodownik Dan, Rabah Sobhia Mruwat, Levi Assi, Moshe Shlomo, Lapidoth Moshe, Ingber Arieh, Mashiah Jacob
Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Postepy Dermatol Alergol. 2022 Feb;39(1):159-163. doi: 10.5114/ada.2022.113606. Epub 2022 Feb 28.
Whether individuals with atopic diseases have a different risk of contact allergy compared to those who are non-atopic is controversial and data are conflicting.
To explore the association between atopy and allergic contact dermatitis (ACD).
This retrospective cross-sectional study included 301 patients referred to a tertiary clinic to evaluate ACD. Demographic details including personal and familial mucosal or cutaneous atopic status were recorded. Patch tests were tailored to their clinical presentations and relevant exposures.
At least 1 positive patch test reaction was observed in 177 patients (59% of the study cohort), of which 52% had a history of atopic diseases, compared with 44% of patients with a negative patch test result ( = 0.2). Additionally, 147 patients had an atopic background, of which 92 (62%) had ≥ 1 positive patch test result, compared with 55% of non-atopic patients ( = 0.2). Nickel sulphate was the most common contact allergen (13.4% of the patch test reactions).
We identified a positive tendency for atopic diseases among individuals with ACD and vice versa. Our study supports the aggregate data from previous studies despite the non-significant differences between the study and control groups. However, further research performed in larger populations of patients is necessary to evaluate the real association between atopy and ACD on a solid basis. Our results indicate the necessity of systematic patch testing in patient setups with atopic background and chronic dermatitis.
与非特应性个体相比，特应性疾病患者发生接触性过敏的风险是否不同存在争议，数据相互矛盾。
探讨特应性与过敏性接触性皮炎（ACD）之间的关联。
这项回顾性横断面研究纳入了301名转诊至三级诊所评估ACD的患者。记录了包括个人和家族黏膜或皮肤特应性状态在内的人口统计学细节。斑贴试验根据其临床表现和相关接触情况进行定制。
177名患者（占研究队列的59%）观察到至少1次阳性斑贴试验反应，其中52%有特应性疾病史，而斑贴试验结果为阴性的患者中这一比例为44%（P = 0.2）。此外，147名患者有特应性背景，其中92名（62%）有≥1次阳性斑贴试验结果，而非特应性患者中这一比例为55%（P = 0.2）。硫酸镍是最常见的接触性变应原（占斑贴试验反应的13.4%）。
我们发现ACD患者中特应性疾病有阳性趋势，反之亦然。尽管研究组和对照组之间差异不显著，但我们的研究支持了先前研究的总体数据。然而，有必要在更大的患者群体中进行进一步研究，以便在坚实的基础上评估特应性与ACD之间的真实关联。我们的结果表明，在有特应性背景和慢性皮炎的患者中进行系统性斑贴试验的必要性。
