Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH.
Dermatitis. 2019 Jan/Feb;30(1):62-66. doi: 10.1097/DER.0000000000000436.
Atopic dermatitis (AD) associated with respiratory atopy may represent a form of systemic contact dermatitis (SCD), whereby AD flares after ingestion or inhalation of allergens.
The aim of the study was to compare the prevalence of positive patch tests to allergens known to cause SCD in AD patients with and without respiratory atopy.
This is a retrospective study of patients with AD patch tested to 23 allergens known to cause SCD. Positive patch tests were compared between AD patients with and without respiratory atopy, stratified by age and wet or dry work occupation.
Children and adolescents, but not adults, with AD and respiratory atopy were more likely than age-matched AD patients without respiratory atopy to have positive patch tests to these allergens (odds ratio, 2.33; 95% confidence interval, 1.13-4.79). Moreover, AD patients with respiratory atopy and engaging in wet work, but not dry work, occupations were more likely than AD patients without respiratory atopy to have positive patch tests to allergens known to cause SCD (odds ratio, 1.47; 95% confidence interval, 1.05-2.06). Thus, respiratory atopy and wet work are associated with sensitization to allergens known to cause SCD in patients with AD, and patch testing may be valuable in identifying systemic triggers of dermatitis in these patients.
与呼吸道过敏相关的特应性皮炎（AD）可能代表一种全身性接触性皮炎（SCD）形式，即 AD 在摄入或吸入过敏原后会出现发作。
本研究旨在比较有和无呼吸道过敏的 AD 患者对已知引起 SCD 的过敏原进行斑贴试验的阳性率。
这是一项回顾性研究，对 23 种已知可引起 SCD 的过敏原进行斑贴试验的 AD 患者。比较了有和无呼吸道过敏的 AD 患者之间的阳性斑贴试验，按年龄和湿或干工作职业分层。
与年龄匹配的无呼吸道过敏的 AD 患者相比，有呼吸道过敏的儿童和青少年 AD 患者更有可能对这些过敏原进行阳性斑贴试验（比值比，2.33；95%置信区间，1.13-4.79）。此外，有呼吸道过敏且从事湿工作而非干工作的 AD 患者比无呼吸道过敏的 AD 患者更有可能对已知引起 SCD 的过敏原进行阳性斑贴试验（比值比，1.47；95%置信区间，1.05-2.06）。因此，呼吸道过敏和湿工作与 AD 患者对已知引起 SCD 的过敏原的致敏有关，斑贴试验可能有助于识别这些患者的皮炎全身性触发因素。
