Feng Jie, Men Weiwei, Yu Xiao, Liu Wenjia, Zhang Shiyu, Liu Jie, Ma Lin
104607Medical School of Chinese People's Liberation Army, Beijing, PR China.
Department of Radiology, The First Medical Center of Chinese People's Liberation Army General Hospital, Beijing, PR China.
Acta Radiol. 2023 Feb;64(2):751-759. doi: 10.1177/02841851221091674. Epub 2022 Apr 4.
The correlation between brain injury and high-altitude (HA) exposure duration (Dur_HA) as well as peripheral oxygen saturation (SpO) remains unclear.
To evaluate the global and regional brain volume differences between HA immigrants and sea-level residents, and the relationship between brain volume with Dur_HA and SpO.
Structural magnetic resonance imaging (MRI) scans were acquired in 33 healthy male HA immigrants (HA group) and 33 matched sea-level male residents (SL group). Differences in global gray matter volume (GMV), white matter volume (WMV), brain parenchyma volume (BV), total intracranial volume (TIV), and the volume-fraction (the ratio of GMV/TIV, WMV/TIV, BV/TIV) were assessed. Regional gray matter differences were investigated using voxel-based morphology analysis. The volume of clusters with GM loss were calculated as the volume of volume of interest (V_VOI). Student's -test and partial correlation were adopted for statistic calculation.
Compared to the SL group, the HA immigrants had larger WMV ( = 0.015), smaller ratio of GMV/WMV ( = 0.022), and regional gray matter loss in bilateral basal ganglion, limbic system, midbrain, and vermis (cluster size >100 voxels, family-wise error corrected at = 0.01). The global GMV, BV, and V_VOI confined to vermis had negative correlations with the Dur_HA (r = -0.369, = 0.049; r = -0.380, = 0.042; and r = -0.471, = 0.010. Neither global nor regional brain volume correlated with SpO.
Global and regional brain are affected by long-term HA exposure, and global and regional gray matter have a time-dependent volume loss.
脑损伤与高海拔（HA）暴露持续时间（Dur_HA）以及外周血氧饱和度（SpO）之间的相关性仍不清楚。
评估HA移民与海平面居民之间的全脑和局部脑容量差异，以及脑容量与Dur_HA和SpO之间的关系。
对33名健康男性HA移民（HA组）和33名匹配的海平面男性居民（SL组）进行结构磁共振成像（MRI）扫描。评估全脑灰质体积（GMV）、白质体积（WMV）、脑实质体积（BV）、总颅内体积（TIV）以及体积分数（GMV/TIV、WMV/TIV、BV/TIV的比值）的差异。使用基于体素的形态学分析研究局部灰质差异。计算灰质损失簇的体积作为感兴趣体积（V_VOI）。采用学生t检验和偏相关进行统计计算。
与SL组相比，HA移民的WMV较大（P = 0.015），GMV/WMV比值较小（P = 0.022），双侧基底神经节、边缘系统、中脑和蚓部存在局部灰质损失（簇大小>100体素，家族性错误校正P = 0.01）。全脑GMV、BV以及局限于蚓部的V_VOI与Dur_HA呈负相关（r = -0.369，P = 0.049；r = -0.380，P = 0.042；r = -0.471，P = 0.010）。全脑和局部脑容量均与SpO无关。
长期HA暴露会影响全脑和局部脑，全脑和局部灰质存在时间依赖性的体积损失。
