胰腺导管腺癌切除术后肺复发的临床病理变量及危险因素
Clinicopathological variables and risk factors for lung recurrence after resection of pancreatic ductal adenocarcinoma.
作者信息
Asakura Yu, Toyama Hirochika, Ishida Jun, Asari Sadaki, Terai Sachio, Shirakawa Sachiyo, Yamashita Hironori, Shimizu Takashi, Ogura Yuta, Matsumoto Ippei, Gon Hidetoshi, Tsugawa Daisuke, Komatsu Shohei, Kuramitsu Kaori, Yanagimoto Hiroaki, Kido Masahiro, Ajiki Tetsuo, Fukumoto Takumi
机构信息
Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
出版信息
Asian J Surg. 2023 Jan;46(1):207-212. doi: 10.1016/j.asjsur.2022.03.043. Epub 2022 Mar 31.
BACKGROUND
Pancreatic ductal adenocarcinoma (PDAC) has a high recurrence rate even after curative resection. Lung recurrence may have better outcomes than other recurrences. However, its detailed clinicopathological features are unclear. We investigated the clinicopathological features and risk factors for lung recurrence after pancreatectomy for PDAC.
METHODS
The study included 161 patients with potentially and borderline resectable PDAC who had undergone R0 or R1 pancreatectomy between January 2008 and December 2016. We retrospectively examined the prognosis and predictors for lung recurrence after curative resection.
RESULTS
Seventeen patients (10.6%) had isolated lung recurrence. The median overall and recurrence-free survivals were 38.0 and 16.1 months, respectively. In multivariate analysis, para-aortic lymph node (PALN) metastasis (p = 0.006) and female sex (p = 0.027) were independent factors for lung recurrence.
CONCLUSION
Lung recurrence had a better prognosis than other recurrences. PALN metastasis and female sex are independent risk factors for lung recurrence after curative resection for PDAC.
背景
胰腺导管腺癌（PDAC）即使在根治性切除术后仍有较高的复发率。肺复发可能比其他部位的复发有更好的预后。然而，其详细的临床病理特征尚不清楚。我们研究了PDAC胰腺切除术后肺复发的临床病理特征及危险因素。
方法
本研究纳入了2008年1月至2016年12月期间接受R0或R1胰腺切除术的161例潜在可切除和临界可切除PDAC患者。我们回顾性分析了根治性切除术后肺复发的预后及预测因素。
结果
17例患者（10.6%）出现孤立性肺复发。总生存期和无复发生存期的中位数分别为38.0个月和16.1个月。多因素分析显示，主动脉旁淋巴结（PALN）转移（p = 0.006）和女性（p = 0.027）是肺复发的独立因素。
结论
肺复发的预后比其他部位的复发更好。PALN转移和女性是PDAC根治性切除术后肺复发的独立危险因素。
Zotero 插件