School of Medicine, Ningbo University, Ningbo, China.
The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China.
Front Immunol. 2022 Mar 16;13:860661. doi: 10.3389/fimmu.2022.860661. eCollection 2022.
MicroRNAs (miRNAs) are endogenous non-coding single-stranded small molecule RNAs consisting of 20-24 nucleotides that are highly conserved in species evolution. Expression of miRNAs is strictly tissue-specific, and it is chronological in fungi and plants, as well as in animals. MiR-223 has been shown to play a key role in innate immunity, and dysregulation of its expression contributes to the pathogenesis of multiple inflammatory diseases, and cancers. In this article the biosynthesis and functions of miR-223 in innate immunity are reviewed, and the role of miR-223 in liver physiopathology and therapeutic prospects are highlighted.
微小 RNA（miRNAs）是内源性非编码单链小分子 RNA，由 20-24 个核苷酸组成，在物种进化中高度保守。miRNAs 的表达具有严格的组织特异性，在真菌和植物以及动物中具有时间特异性。已经证明 miR-223 在先天免疫中发挥关键作用，其表达的失调导致多种炎症性疾病和癌症的发病机制。本文综述了 miR-223 在先天免疫中的生物合成和功能，并强调了 miR-223 在肝脏生理病理和治疗前景中的作用。
