Kidney Disease Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, China.
Front Immunol. 2022 Mar 17;13:840857. doi: 10.3389/fimmu.2022.840857. eCollection 2022.
Previous reports showed that some patients with minimal change disease (MCD) had high serum immunoglobulin E (IgE) levels. This study aimed to explore the proportion of MCD patients with high serum IgE levels and evaluate the correlation between serum IgE levels and MCD remission and relapse.
This study enrolled 222 new-onset patients with renal biopsy-confirmed MCD from October 2012 to October 2019 at the First Affiliated Hospital of Zhejiang University in Hangzhou, China. Patients' demographics and clinical parameters were analyzed.
The results indicated that 70.3% of 222 MCD patients had high serum IgE levels (IgE > 100.0 IU/mL). Moreover, 134 patients were treated with glucocorticoids alone and divided into the low- and high-IgE groups, according to the median serum IgE level (523.5 IU/mL). The mean time to complete remission of the low- and high-IgE groups was 29.0 ± 2.2 and 45.7 ± 4.2 days, respectively (log-rank test; = 0.002). The mean time to total remission was 19.1 ± 1.4 and 31.6 ± 3.2 days of the low- and high-IgE groups, respectively (log-rank test; < 0.001). The mean time to first relapse in the low- and high-IgE groups was 701.2 ± 65.0 and 425.0 ± 52.6 days, respectively (log-rank test; = 0.002). Serum IgE ≥ 523.5 IU/mL was an independent correlation factor affecting the patients' remission and relapse.
Serum IgE level was an independent correlation factor for MCD remission and relapse. MCD patients with high serum IgE levels were prone to delayed remissions and early relapses.
先前的报告显示，一些微小病变性肾病（MCD）患者的血清免疫球蛋白 E（IgE）水平较高。本研究旨在探讨 MCD 患者高血清 IgE 水平的比例，并评估血清 IgE 水平与 MCD 缓解和复发的相关性。
本研究纳入了 2012 年 10 月至 2019 年 10 月期间在浙江大学附属第一医院经肾活检确诊的 222 例新发病例的 MCD 患者。分析患者的人口统计学和临床参数。
结果表明，222 例 MCD 患者中有 70.3%（IgE＞100.0 IU/ml）存在高血清 IgE 水平。此外，134 例患者单独接受糖皮质激素治疗，根据血清 IgE 中位数（523.5 IU/ml）分为低 IgE 组和高 IgE 组。低 IgE 组和高 IgE 组完全缓解的平均时间分别为 29.0±2.2 和 45.7±4.2 天（对数秩检验； = 0.002）。低 IgE 组和高 IgE 组完全缓解的平均时间分别为 19.1±1.4 和 31.6±3.2 天（对数秩检验； ＜0.001）。低 IgE 组和高 IgE 组首次复发的平均时间分别为 701.2±65.0 和 425.0±52.6 天（对数秩检验； = 0.002）。血清 IgE≥523.5 IU/ml 是影响患者缓解和复发的独立相关因素。
血清 IgE 水平是影响 MCD 缓解和复发的独立相关因素。高血清 IgE 水平的 MCD 患者易出现缓解延迟和早期复发。
