Ciprofloxacin salt and salt co-crystal with di-hydroxy-benzoic acids.

作者信息

Nugraha Yuda Prasetya, Sugiyama Haruki, Uekusa Hidehiro

机构信息

Department of Pharmaceutics, School of Pharmacy, Bandung Institute of Technology, Bandung 40132, Indonesia.

Research and Education Center for Natural Sciences, Keio University, Hiyoshi, 4-1-1, Kohoku, Yokohama 223-8521, Japan.

出版信息

Acta Crystallogr E Crystallogr Commun. 2022 Feb 3;78(Pt 3):259-263. doi: 10.1107/S2056989022001177. eCollection 2022 Feb 1.

The crystal structure of two multi-component crystals of ciprofloxacin [systematic name: 1-cyclo-propyl-6-fluoro-4-oxo-7-(piperazin-1-yl)quinoline-3-carb--oxy-lic acid], a fluoro-quinolone anti-biotic, namely, ciprofloxacin 2,6-di-hydroxy-benzoate salt, CHFNO ·CHO , (I), and ciprofloxacin hydro-chloride-3,5-di-hydroxy-benzoic-water (1/1/1), CHFNO ·Cl·CHO·HO, (II), were determined. In (I) and (II), the ciprofloxacin cations are connected head-to-tail N-H⋯O hydrogen bonding. Both structures show an alternating layered arrangement between ciprofloxacin and di-hydroxy-benzoic acid.