Zevallos M, Cone L A, Kaminsky D B
J Neurooncol. 1986;4(2):183-6. doi: 10.1007/BF00165381.
Histologic conversion of a less aggressive non-Hodgkin's lymphoma to a more aggressive type has been established in several studies. Neither this trend nor vice versa has been reported in primary brain lymphoma, because of the poor median survival in the clinical setting which precludes further invasive procedures. The authors report a case of transformation of a primary brain lymphoma, histiocytic type, to poorly differentiated lymphocytic lymphoma 2 1/2 years after treatment with radiation and intrathecal methotrexate.
多项研究已证实，侵袭性较低的非霍奇金淋巴瘤可组织学转化为侵袭性更强的类型。原发性脑淋巴瘤尚未见这种转化趋势或相反情况的报道，因为临床环境中患者的中位生存期较短，无法进行进一步的侵入性检查。作者报告了1例原发性脑淋巴瘤（组织细胞型）在接受放疗和鞘内注射甲氨蝶呤治疗2年半后转化为低分化淋巴细胞淋巴瘤的病例。
