Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Front Public Health. 2022 Mar 18;10:827853. doi: 10.3389/fpubh.2022.827853. eCollection 2022.
Mixed urinary incontinence increasingly undermines women's quality of life. Previous studies showed some effects of acupuncture for MUI, but no systematic review has been done to evaluate the efficacy and safety of acupuncture for MUI in women.
To systematically review the efficacy and safety of acupuncture for women with MUI.
Ten databases (i.e., PubMed, Web of Science, Embase, ClinicalTrials.gov, the Cochrane Library, CBM, Scoups, CNKI, VIP and WANFANG DATA) were searched up to July 19th, 2021, using tailored search strategies with keywords not limited to "female," "mixed urinary incontinence," "acupuncture," and "randomized controlled trial," etc. RCTs and quasi-RCTs were included if investigating effect of any type of acupuncture for female patients with MUI. Data were extracted from eligible studies, and risks of bias were assessed according to the Cochrane Handbook from seven aspects using the RevMan 5.4 software.
A total of three randomized studies with 591 women were included. The risk of bias among the studies varied, with major concerns on blinding of participants and outcome assessor. Liu's study (497) mainly showed that electroacupuncture's effect on reduction of numbers of incontinence, urgency, nocturia episodes, and amount of urine leakage etc. was not inferior to that of PFMT-Solifenacin group at 12, 24, and 36 weeks. Zhan's study (60) showed that electroacupuncture reduced significantly more amount of urine leakage than Tolterodine at 8 weeks, with no data on incontinence episodes frequency. All 3 studies reported that acupuncture significantly increased the quality of life assessed by ICIQ score. In addition, incidence of acupuncture-related adverse events was rare, while antimuscarinic agents related adverse events were common in two studies.
Although acupuncture showed some benefit for women with MUI, more evidences were required to draw a solid conclusion of effectiveness and safety of acupuncture for women with MUI.
https://www.crd.york.ac.uk/PROSPERO, identifier: CRD42021224600.
混合性尿失禁越来越多地影响女性的生活质量。既往研究表明针灸对混合性尿失禁有一定效果，但尚无系统评价来评估针灸治疗女性混合性尿失禁的疗效和安全性。
系统评价针灸治疗女性混合性尿失禁的疗效和安全性。
检索 10 个数据库（PubMed、Web of Science、Embase、ClinicalTrials.gov、Cochrane 图书馆、CBM、Scopus、中国知网、维普网和万方数据知识服务平台），检索时间截至 2021 年 7 月 19 日，使用定制的检索策略，关键词不限于“女性”“混合性尿失禁”“针灸”和“随机对照试验”等。纳入研究类型为针灸治疗女性混合性尿失禁的随机对照试验和半随机对照试验。使用 RevMan 5.4 软件，从 7 个方面按照 Cochrane 手册评估偏倚风险。
共纳入 3 项随机研究，包含 591 名女性。研究的偏倚风险不同，主要关注于参与者和结局评估者的盲法。Liu 等的研究（497 名女性）主要表明，电针对减少尿失禁、尿急、夜尿和漏尿量等方面的疗效在 12、24 和 36 周时不劣于 PFMT-索利那新组。Zhan 等的研究（60 名女性）表明，电针在 8 周时显著减少漏尿量多于托特罗定，但是没有尿急发作频率的数据。3 项研究均报道，针灸显著提高了 ICIQ 评分评估的生活质量。此外，针灸相关不良事件的发生率较低，而两种研究中均报道了抗胆碱能药物相关不良事件较为常见。
虽然针灸对女性混合性尿失禁有一定效果，但仍需要更多证据来得出针灸治疗女性混合性尿失禁有效性和安全性的可靠结论。
