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病例报告:腹腔镜直肠癌手术后盆腔壁梭菌性气性坏疽引发致命性脓毒症

Case Report: Clostridial Gas Gangrene of Pelvic Wall After Laparoscopic Rectal Cancer Surgery Induced Fatal Sepsis.

作者信息

Wang Xing, Jiao Simin, Sun Zhen, Wang Zhicheng, Wang Xudong, Liu Tianzhou

机构信息

Department of Gastrointestinal Surgery, The Second Hospital of Jilin University, Changchun, China.

出版信息

Front Surg. 2022 Mar 18;9:822605. doi: 10.3389/fsurg.2022.822605. eCollection 2022.

DOI:10.3389/fsurg.2022.822605
PMID:35372485
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8971600/
Abstract

Clostridial gas gangrene is an unusual but fast-spreading necrotic infection of soft tissue relevant to high mortality rates. We report a case of postoperative gas gangrene of the pelvic wall, scrotum, and perineal site, with very acute onset and rapid progression of symptoms after laparoscopic radical resection for rectal cancer. Although potentially treatable with appropriate antibiotic cover and urgent thorough surgical debridement, this case still developed irreversibly into fulminant and fatal sepsis. The possible etiologic factors, better measures of diagnosis, and treatment are discussed, and the relevant literature is reviewed.

摘要

梭菌性气性坏疽是一种罕见但快速蔓延的软组织坏死感染,与高死亡率相关。我们报告一例盆腔壁、阴囊及会阴部位的术后气性坏疽病例,该病例在腹腔镜直肠癌根治切除术后起病极急,症状进展迅速。尽管通过适当的抗生素覆盖及紧急彻底的手术清创有可能治愈,但该病例仍不可逆转地发展为暴发性致命性脓毒症。本文讨论了可能的病因、更好的诊断方法及治疗措施,并对相关文献进行了综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/795b/8971600/5121d747300f/fsurg-09-822605-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/795b/8971600/403f5cee6d49/fsurg-09-822605-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/795b/8971600/ff3c433f617b/fsurg-09-822605-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/795b/8971600/5121d747300f/fsurg-09-822605-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/795b/8971600/403f5cee6d49/fsurg-09-822605-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/795b/8971600/ff3c433f617b/fsurg-09-822605-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/795b/8971600/5121d747300f/fsurg-09-822605-g0003.jpg

相似文献

1
Case Report: Clostridial Gas Gangrene of Pelvic Wall After Laparoscopic Rectal Cancer Surgery Induced Fatal Sepsis.病例报告:腹腔镜直肠癌手术后盆腔壁梭菌性气性坏疽引发致命性脓毒症
Front Surg. 2022 Mar 18;9:822605. doi: 10.3389/fsurg.2022.822605. eCollection 2022.
2
Hyperbaric oxygen therapy in acute necrotizing infections with a special reference to the effects on tissue gas tensions.高压氧疗法在急性坏死性感染中的应用,特别提及对组织气体张力的影响。
Ann Chir Gynaecol Suppl. 2000(214):7-36.
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Clostridial Gas Gangrene - A Rare but Deadly Infection: Case series and Comparison to Other Necrotizing Soft Tissue Infections.梭状芽孢杆菌性气性坏疽——一种罕见但致命的感染:病例系列及与其他坏死性软组织感染的比较。
Orthop Surg. 2020 Dec;12(6):1733-1747. doi: 10.1111/os.12804. Epub 2020 Oct 4.
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Eur J Surg Suppl. 1993(570):1-36.
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[Fatal course of a fulminant gas gangrene of the right hemithorax].[右侧全胸暴发性气性坏疽的致命病程]
Unfallchirurgie (Heidelb). 2025 Jan;128(1):59-63. doi: 10.1007/s00113-024-01490-6. Epub 2024 Oct 10.
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Hyperbaric oxygen therapy in acute necrotizing infections. With a special reference to the effects on tissue gas tensions.急性坏死性感染中的高压氧疗法。特别提及对组织气体张力的影响。
Ann Chir Gynaecol. 2000;89 Suppl 214:7-36.
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[Clostridial sepsis and gas gangrene of the abdominal wall after cholecystectomy].
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Fournier's gangrene in a rectal cancer patient.一名直肠癌患者发生福尼埃坏疽。
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A case of acute onset postoperative gas gangrene caused by Clostridium perfringens.一例由产气荚膜梭菌引起的急性术后气性坏疽病例。
BMC Res Notes. 2016 Aug 3;9:385. doi: 10.1186/s13104-016-2194-0.

本文引用的文献

1
Clostridial Gas Gangrene - A Rare but Deadly Infection: Case series and Comparison to Other Necrotizing Soft Tissue Infections.梭状芽孢杆菌性气性坏疽——一种罕见但致命的感染:病例系列及与其他坏死性软组织感染的比较。
Orthop Surg. 2020 Dec;12(6):1733-1747. doi: 10.1111/os.12804. Epub 2020 Oct 4.
2
Necrotizing Soft-Tissue Infections.坏死性软组织感染
N Engl J Med. 2017 Dec 7;377(23):2253-2265. doi: 10.1056/NEJMra1600673.
3
Rare postoperative complication: septic shock following elective abdominal surgery.罕见的术后并发症:择期腹部手术后发生感染性休克。
BMJ Case Rep. 2017 Oct 9;2017:bcr-2017-221980. doi: 10.1136/bcr-2017-221980.
4
Clostridial Gas Gangrene of the Abdominal Wall After Laparoscopic Cholecystectomy: A Case Report and Review.腹腔镜胆囊切除术后腹壁梭菌性气性坏疽:一例报告及文献复习
Surg Laparosc Endosc Percutan Tech. 2016 Aug;26(4):278-81. doi: 10.1097/SLE.0000000000000294.
5
A case of acute onset postoperative gas gangrene caused by Clostridium perfringens.一例由产气荚膜梭菌引起的急性术后气性坏疽病例。
BMC Res Notes. 2016 Aug 3;9:385. doi: 10.1186/s13104-016-2194-0.
6
Clostridium perfringens α-Toxin Impairs Innate Immunity via Inhibition of Neutrophil Differentiation.产气荚膜梭菌α-毒素通过抑制中性粒细胞分化来破坏先天免疫。
Sci Rep. 2016 Jun 16;6:28192. doi: 10.1038/srep28192.
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[Clostridium perfringens].产气荚膜梭菌
Nihon Rinsho. 2012 Aug;70(8):1357-61.
8
Prevention and treatment of surgical site infection: summary of NICE guidance.手术部位感染的预防与治疗:英国国家卫生与临床优化研究所指南摘要
BMJ. 2008 Oct 28;337:a1924. doi: 10.1136/bmj.a1924.
9
Microbiology and management of soft tissue and muscle infections.软组织和肌肉感染的微生物学与管理
Int J Surg. 2008 Aug;6(4):328-38. doi: 10.1016/j.ijsu.2007.07.001. Epub 2007 Jul 15.
10
Clostridium perfringens alpha-toxin: characterization and mode of action.产气荚膜梭菌α毒素:特性与作用方式
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