Ogawa M, Imajo K
Gan No Rinsho. 1986 Aug;32(10):1089-94.
In general, progress of chemotherapy for advanced gastrointestinal tumors has been slow, however, introduction of cisplatin has improved the results of chemotherapy in esophageal cancer. Cisplatin has been also recognized to be active for gastric cancer and study of combinations containing it is underway. Adriamycin appears to be the most active for hepatoma and 5-fluorouracil for pancreatic and colorectal cancers. Thus, combinations containing these drugs have been extensively studied but none has shown a definitive superiority over single agent efficacy of both drugs.
总体而言，晚期胃肠道肿瘤的化疗进展缓慢，然而，顺铂的引入改善了食管癌的化疗效果。顺铂对胃癌也有活性，目前正在进行含顺铂联合方案的研究。阿霉素对肝癌似乎最具活性，5-氟尿嘧啶对胰腺癌和结直肠癌最具活性。因此，含这些药物的联合方案已得到广泛研究，但均未显示出比单药疗效有明确优势。
