Department of Radiation Oncology, ACTREC/TMH, Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai, 400012, India.
Department of Neuro-surgical Oncology, ACTREC/TMH, Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai, 400012, India.
CNS Oncol. 2022 Jun 1;11(2):CNS83. doi: 10.2217/cns-2022-0004. Epub 2022 Apr 4.
To assess systemic inflammatory biomarkers in non invasive differential diagnosis of primary central nervous system lymphoma (PCNSL) from high-grade glioma (HGG). Patients with similar morphology (PCNSL or HGG) on conventional neuro-imaging were included. Systemic inflammatory indices were calculated from pretreatment complete blood counts and liver function tests and compared against histopathology as reference standard. Mean values of absolute lymphocyte count and prognostic nutritional index were significantly different between PCNSL (n = 42) versus HGG (n = 16). Area under receiver operating characteristics curve for absolute lymphocyte count and prognostic nutritional index in the diagnosis of PCNSL was 0.70 and 0.72 respectively suggesting fair and acceptable diagnostic accuracy. Systemic inflammatory biomarkers complement established clinico-radiological features and aid in the differential diagnosis of PCNSL from HGG.
评估系统炎症生物标志物在原发性中枢神经系统淋巴瘤（PCNSL）与高级别胶质瘤（HGG）的非侵袭性鉴别诊断中的作用。纳入常规神经影像学检查具有相似形态的患者（PCNSL 或 HGG）。从预处理的全血细胞计数和肝功能检查中计算出系统炎症指数，并与组织病理学作为参考标准进行比较。PCNSL（n=42）与 HGG（n=16）之间的绝对淋巴细胞计数和预后营养指数的平均值有显著差异。绝对淋巴细胞计数和预后营养指数在诊断 PCNSL 中的受试者工作特征曲线下面积分别为 0.70 和 0.72，表明具有良好和可接受的诊断准确性。系统炎症生物标志物补充了既定的临床影像学特征，并有助于 PCNSL 与 HGG 的鉴别诊断。
