Young V R
Fed Proc. 1979 May;38(6):1994-2000.
The interrelationships between diet and life span are reviewed, with emphasis on results obtained in studies with experimental animals. Ad libitum feeding throughout life does not promote maximal survival and food restriction increases mean life span. The possible importance of total energy, carbohydrate, and protein intake are considered, as well as the influence of mode of feeding. A number of mechanisms that might explain how nutrition affects life span are discussed, including disease pattern, free radicals, neuroendocrine system, and protein turnover. The significance of these findings in relation to the health and life span of human subjects is not known and deserves further exploration. However, they emphasize the importance of diet as a tool to help explore the biochemical and physiological basis for aging in animal models.
本文综述了饮食与寿命之间的相互关系，重点关注在实验动物研究中获得的结果。终生随意进食并不能促进最大程度的存活，而食物限制可延长平均寿命。文中考虑了总能量、碳水化合物和蛋白质摄入量的潜在重要性，以及喂养方式的影响。讨论了一些可能解释营养如何影响寿命的机制，包括疾病模式、自由基、神经内分泌系统和蛋白质更新。这些发现在人类健康和寿命方面的意义尚不清楚，值得进一步探索。然而，它们强调了饮食作为一种工具在帮助探索动物模型衰老的生化和生理基础方面的重要性。
