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自发性多支冠状动脉痉挛在诊断性冠状动脉造影术中。

Spontaneous Multivessel Coronary Spasm During Diagnostic Coronary Angiography.

机构信息

College of Medicine, University of Central Florida; Orlando, Florida.

Department of Internal Medicine, HCA Healthcare Greater Orlando; Orlando, Florida.

出版信息

Tex Heart Inst J. 2022 Mar 1;49(2). doi: 10.14503/THIJ-20-7357.

DOI:10.14503/THIJ-20-7357
PMID:35377456
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9053660/
Abstract

Acute vasospastic angina, formerly known as Prinzmetal angina, is characterized by transient electrocardiographic changes that are not related to exertion. Its atypical presentation makes it difficult to establish the diagnosis, so it is probably underrecognized and therefore mismanaged. We treated a 49-year-old woman who presented with a 2-day history of chest pain associated with palpitations. Abnormal radionuclide stress test results prompted diagnostic coronary angiography, during which the patient reported chest pain and became hemodynamically unstable. Active coronary vasospasm at multiple sites was treated with intracoronary nitroglycerin and nicardipine, leading to immediate recovery. Our case highlights the importance of accurate, timely diagnosis of vasospastic angina, and of early recognition and management of spontaneous coronary spasm during angiography.

摘要

急性血管痉挛性心绞痛,以前称为变异型心绞痛,其特征为与体力活动无关的短暂心电图改变。其不典型的表现使其难以建立诊断,因此可能被低估和治疗不当。我们治疗了一位 49 岁的女性,她有 2 天的胸痛伴心悸病史。异常的放射性核素应激试验结果促使进行诊断性冠状动脉造影,在此期间患者报告胸痛并出现血液动力学不稳定。多处冠状动脉痉挛采用冠状动脉内硝酸甘油和尼卡地平治疗,立即得到缓解。我们的病例强调了准确、及时诊断血管痉挛性心绞痛的重要性,以及在血管造影期间早期识别和处理自发性冠状动脉痉挛的重要性。

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Spontaneous Multivessel Coronary Spasm During Diagnostic Coronary Angiography.自发性多支冠状动脉痉挛在诊断性冠状动脉造影术中。
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Pharmacological coronary spasm provocative testing in clinical practice: A French Coronary Atheroma and Interventional Cardiology Group (GACI) position paper.临床实践中的药理学冠状动脉痉挛激发试验:法国冠状动脉粥样硬化和介入心脏病学组(GACI)立场文件。
Arch Cardiovasc Dis. 2023 Dec;116(12):590-596. doi: 10.1016/j.acvd.2023.10.002. Epub 2023 Oct 13.

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本文引用的文献

1
Intracoronary nitroglycerin: recognizing coronary spasm first and foremost to avoid unnecessary coronary stents.冠状动脉内注射硝酸甘油:首要的是识别冠状动脉痉挛以避免不必要的冠状动脉支架置入。
Expert Rev Cardiovasc Ther. 2017 Oct;15(10):727-728. doi: 10.1080/14779072.2017.1365601. Epub 2017 Aug 17.
2
Impact of Statin Therapy on Clinical Outcome in Patients With Coronary Spasm.他汀类药物治疗对冠状动脉痉挛患者临床结局的影响。
J Am Heart Assoc. 2016 May 20;5(5):e003426. doi: 10.1161/JAHA.116.003426.
3
Angiographic Characteristics of Catheter-Induced Spasm of the Left Main Coronary Artery.导管诱导的左主干冠状动脉痉挛的血管造影特征
Am J Cardiol. 2016 Feb 15;117(4):571-573. doi: 10.1016/j.amjcard.2015.11.039. Epub 2015 Dec 7.
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2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC).2015年欧洲心脏病学会(ESC)非持续性ST段抬高型急性冠脉综合征患者管理指南:欧洲心脏病学会(ESC)非持续性ST段抬高型急性冠脉综合征患者管理工作组
Eur Heart J. 2016 Jan 14;37(3):267-315. doi: 10.1093/eurheartj/ehv320. Epub 2015 Aug 29.
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International standardization of diagnostic criteria for vasospastic angina.血管痉挛性心绞痛诊断标准的国际化。
Eur Heart J. 2017 Sep 1;38(33):2565-2568. doi: 10.1093/eurheartj/ehv351.
6
Guidelines for diagnosis and treatment of patients with vasospastic angina (Coronary Spastic Angina) (JCS 2013).变异性心绞痛(冠状动脉痉挛性心绞痛)患者的诊断和治疗指南(日本循环学会2013年版)
Circ J. 2014;78(11):2779-801. doi: 10.1253/circj.cj-66-0098. Epub 2014 Sep 30.
7
Coronary artery spasm and thyrotoxicosis: the best index is that of suspicion.冠状动脉痉挛与甲状腺毒症:最佳指标是怀疑指标。
Coron Artery Dis. 2014 Mar;25(2):96-7. doi: 10.1097/MCA.0000000000000070.
8
Effects of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, fluvastatin, on coronary spasm after withdrawal of calcium-channel blockers.3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂氟伐他汀对停用钙通道阻滞剂后冠状动脉痉挛的影响。
J Am Coll Cardiol. 2008 May 6;51(18):1742-8. doi: 10.1016/j.jacc.2007.12.049.
9
Angina pectoris. I. A variant form of angina pectoris; preliminary report.心绞痛。一、心绞痛的一种变异形式;初步报告。
Am J Med. 1959 Sep;27:375-88. doi: 10.1016/0002-9343(59)90003-8.
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Refractory vasomotor angina in subclinical hyperthyroidism demonstrating focal and segmental coronary vasoconstriction.亚临床甲状腺功能亢进症中的难治性血管运动性心绞痛表现为局灶性和节段性冠状动脉血管收缩。
J Invasive Cardiol. 2003 May;15(5):289-92.