Azmi Atiqah Nabieha, Wan Ismail Wan Zakiah, Abu Hassan Haslan, Halim Mohd Mahadi, Zainal Norzaini, Muskens Otto L, Wan Ahmad Kamil Wan Maryam
School of Physics, Universiti Sains Malaysia, 11800 Penang, Malaysia.
Faculty of Engineering and Built Environment, Universiti Sains Islam Malaysia, 71800, Nilai, Negeri Sembilan, Malaysia.
ACS Sens. 2022 Apr 22;7(4):914-928. doi: 10.1021/acssensors.1c02749. Epub 2022 Apr 4.
In this review, the concept of open cavity lasing for ultrasensitive sensing is explored, specifically in driving important innovations as laser-based biosensors─a field mostly dominated by fluorescence-based sensing. Laser-based sensing exhibits higher signal amplification and lower signal-to-noise ratio due to narrow emission lines as well as high sensitivity due to nonlinear components. The versatility of open cavity random lasers for probing analytes directly which is ultrasensitive to small changes in chemical composition and temperature fluctuations paves the path of utilizing narrow emission lines for advanced sensing. The concept of random lasing is first explained followed by a comparison of the different lasing threshold that has been reported. This is followed by a survey of reports on laser-based sensing and more specifically as biosensors. Finally, a perspective on the way forward for open cavity laser-based sensing is put forth.
在本综述中，探讨了用于超灵敏传感的开放腔激光概念，特别是在推动基于激光的生物传感器这一重要创新方面，该领域大多由基于荧光的传感主导。基于激光的传感由于发射线窄而具有更高的信号放大率和更低的信噪比，并且由于非线性成分而具有高灵敏度。开放腔随机激光器直接探测分析物的多功能性，对化学成分和温度波动的微小变化超灵敏，为利用窄发射线进行先进传感铺平了道路。首先解释随机激光的概念，然后比较已报道的不同激光阈值。接着对基于激光的传感，更具体地说是作为生物传感器的报告进行综述。最后，对基于开放腔激光传感的未来发展方向提出展望。
