Department of Neuroscience "Rita Levi Montalcini", University of Turin, Via Cherasco 15, 10124, Turin, Italy.
Department of Neuroscience "Rita Levi Montalcini", University of Turin, Via Cherasco 15, 10124, Turin, Italy.
Parkinsonism Relat Disord. 2022 Apr;97:91-98. doi: 10.1016/j.parkreldis.2022.03.006. Epub 2022 Mar 30.
Postural abnormalities (PA) are disabling features of Parkinson's disease (PD). Indirect analyses suggested a higher prevalence of PA among Asian patients compared to Caucasian ones, but no direct comparisons have been performed so far.
An international, multicenter, cross-sectional study was performed in 6 European and Asian movement disorders centers with the aim to clarify differences and similarities of prevalence and characteristics of PA in Asian vs. Caucasian PD patients. Axial PA, encompassing antecollis (AC), camptocormia (CC), and Pisa syndrome (PS), and appendicular PA (appPA) were systematically searched and analysed in consecutive patients.
88 (27%) of 326 PD patients had PA (29.1% in Asians and 24.3% in Caucasians, p: 0.331). Prevalence of axial PA was 23.6% in Asians and 24.3% in Caucasians (p = 0.886), in spite of a longer disease duration among Caucasians, but a longer PA duration among Asians. No differences in prevalence between AC, CC, and PS were found between the two ethnicities. The prevalence of appPA was higher in Asians (p = 0.036), but the regression analysis did not confirm a significant difference related to ethnicity. Considering the whole population, male gender (OR, 4.036; 95% CI, 1.926-8.456; p < 0.005), a longer disease duration (OR, 2.61; 95% CI, 1.024-6.653; p = 0.044), and a higher axial score (OR, 1.242; 95% CI, 1.122-1.375; p < 0.0005) were the factors associated with axial PA.
The prevalence of axial PA in PD patients is not influenced by ethnicity. However, Asian PD patients tend to develop PA earlier in the disease course, particularly AC.
姿势异常（PA）是帕金森病（PD）的致残特征。间接分析表明，亚洲患者的 PA 患病率高于白种人，但迄今为止尚未进行直接比较。
在 6 个欧洲和亚洲运动障碍中心进行了一项国际、多中心、横断面研究，旨在阐明亚洲与白种人 PD 患者 PA 的患病率和特征的差异和相似之处。连续患者系统地搜索和分析了轴向 PA（包括前屈颈征（AC）、驼背（CC）和比萨综合征（PS））和附属 PA（appPA）。
326 例 PD 患者中有 88 例（27%）存在 PA（亚洲患者为 29.1%，白种人为 24.3%，p：0.331）。亚洲人的轴向 PA 患病率为 23.6%，白种人为 24.3%（p=0.886），尽管白种人的疾病持续时间较长，但亚洲人的 PA 持续时间较长。两种族之间没有发现 AC、CC 和 PS 之间的患病率差异。亚洲人的 appPA 患病率较高（p=0.036），但回归分析并未证实与种族有关的显著差异。考虑到整个人群，男性（OR，4.036；95%CI，1.926-8.456；p<0.005）、较长的疾病持续时间（OR，2.61；95%CI，1.024-6.653；p=0.044）和较高的轴向评分（OR，1.242；95%CI，1.122-1.375；p<0.0005）是与轴向 PA 相关的因素。
PD 患者的轴向 PA 患病率不受种族影响。然而，亚洲 PD 患者在疾病过程中较早出现 PA，尤其是 AC。
