日本帕金森病患者的脊柱前凸：一项多中心研究。
Camptocormia in Japanese patients with Parkinson's disease: a multicenter study.
机构信息
Department of Neurology, Keio University School of Medicine, Tokyo, Japan.
出版信息
Mov Disord. 2011 Dec;26(14):2567-71. doi: 10.1002/mds.23955. Epub 2011 Sep 27.
OBJECTIVE
The aim of this work was to investigate the prevalence of camptocormia and the clinical characteristics of patients with camptocormia in a large population of PD patients.
BACKGROUND
Although camptocormia has been recognized as a prominent phenomenon in PD, the previous epidemiological reports were limited, especially in terms of sample size.
METHODS
We evaluated 531 PD patients (disease duration: 7.0 ± 5.5 years, mean ± standard deviation). We examined their clinical features and the prevalence of camptocormia.
RESULTS
Camptocormia was detected in 22 patients (4.1%) and found in patients who were older and had more severe motor symptoms and a higher levodopa (L-dopa) dose (P < 0.05), compared to the patients without camptocormia. Patients with camptocormia showed significantly higher frequencies of autonomic symptoms, such as constipation and urinary incontinence (P < 0.05).
CONCLUSIONS
Camptocormia is uncommon in PD and is associated with disease severity, higher L-dopa dose and higher frequencies of autonomic symptoms.
目的
本研究旨在调查大样本帕金森病（PD）患者中脊柱前屈畸形的患病率及其临床特征。
背景
尽管脊柱前屈畸形已被认为是 PD 的一个突出表现，但之前的流行病学报道数量有限，尤其是在样本量方面。
方法
我们评估了 531 名 PD 患者（病程：7.0±5.5 年，平均值±标准差）。我们检查了他们的临床特征和脊柱前屈畸形的患病率。
结果
22 名患者（4.1%）出现脊柱前屈畸形，与无脊柱前屈畸形的患者相比，这些患者年龄更大，运动症状更严重，左旋多巴（L-dopa）剂量更高（P＜0.05）。脊柱前屈畸形患者更常出现自主神经症状，如便秘和尿失禁（P＜0.05）。
结论
PD 中脊柱前屈畸形并不常见，与疾病严重程度、L-dopa 剂量更高和更高频率的自主神经症状有关。
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