长链非编码 RNA MIR600HG 通过调控 miR-144-3p/KIF3A 诱导结直肠癌细胞的增殖和侵袭。
lncRNA MIR600HG induces the proliferation and invasion of colorectal cancer cells via regulating miR-144-3p/KIF3A.
机构信息
Department of General Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121000, Liaoning, PR China.
Department of Anesthesiology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121000, Liaoning, PR China.
出版信息
Int Immunopharmacol. 2022 Jul;108:108686. doi: 10.1016/j.intimp.2022.108686. Epub 2022 Apr 1.
Colorectal cancer (CRC) is a common digestive system malignancy characterized by the high morbidity and mortality rates. Due to the limited therapeutic options, the majority of CRC patients do not receive timely treatment, which has thus increased the risk of tumor recurrence. Long noncoding RNAs (lncRNAs), as the essential regulators, are involved in numerous pivotal physiological and pathological processes in CRC. By qRT-PCR, it could be discovered in this study that MIR600HG expression obviously increased in CRC tissues and cell lines compared with the normal group. Moreover, the high expression of MIR600HG was correlated with tumor size, tumor volume and TNM stage. Overexpression of MIR600HG affected the expression of downstream molecules, such as miR-144-3p and KIF3A, providing the possible mechanisms of MIR600HG in the development and progression of CRC.
结直肠癌（CRC）是一种常见的消化系统恶性肿瘤，其发病率和死亡率都很高。由于治疗选择有限，大多数 CRC 患者不能得到及时治疗，这增加了肿瘤复发的风险。长链非编码 RNA（lncRNA）作为重要的调节因子，参与 CRC 中许多关键的生理和病理过程。通过 qRT-PCR，本研究发现 MIR600HG 在 CRC 组织和细胞系中的表达明显高于正常组。此外，MIR600HG 的高表达与肿瘤大小、肿瘤体积和 TNM 分期有关。MIR600HG 的过表达影响下游分子的表达，如 miR-144-3p 和 KIF3A，为 MIR600HG 在 CRC 发生和发展中的可能机制提供了依据。
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