Kaur Simrandeep, Gill Karamjit S, Manjari Mridu, Kumar Surinder, Nauhria Shreya, Nath Reetuparna, Patel Chandni, Hamdan Kamal, Jeong Yujin, Nayak Narendra P, Maity Sabyasachi, Hilgers Rob, Nauhria Samal
Department of Pathology, Sri Guru Ram Das Institute of Medical Sciences & Research, Amritsar, IND.
Department of Community Medicine, Armed Forces Medical College, Pune, IND.
Cureus. 2022 Mar 3;14(3):e22811. doi: 10.7759/cureus.22811. eCollection 2022 Mar.
Objective In this study, we aimed to explore the potential diagnostic utility of human epidermal growth factor receptor 2 (HER2) expression in colorectal carcinoma. We investigated the association of HER2 expression with the type and grade of the tumor along with the pattern, staining intensity, and the percentage of cells stained. Methods This was an observational study involving 50 cases of colorectal carcinoma that underwent immunohistochemistry to analyze the HER2 expression. Results The positive expression of HER2 was seen in 16 (32%) cases. The majority of the study population was between the fifth-seventh decades of life. The most commonly diagnosed tumor was conventional adenocarcinoma with grade II, cytoplasmic pattern, +2 positivity, and moderate intensity. The maximum positivity for HER2 was seen in tumors of the rectum in eight (16%) cases. Conclusion A substantial rate of HER2 overexpression paves the way for it to become a potential future target in cancer therapeutics.
目的 在本研究中，我们旨在探讨人表皮生长因子受体2（HER2）表达在结直肠癌中的潜在诊断效用。我们研究了HER2表达与肿瘤类型、分级以及染色模式、染色强度和染色细胞百分比之间的关联。方法 这是一项观察性研究，纳入50例接受免疫组织化学分析HER2表达的结直肠癌病例。结果 在16例（32%）病例中观察到HER2阳性表达。研究人群大多处于50至70岁之间。最常诊断的肿瘤是II级常规腺癌，呈细胞质模式，阳性为+2，强度中等。在8例（16%）直肠肿瘤中观察到HER2的最高阳性率。结论 HER2过表达的相当比例为其成为未来癌症治疗的潜在靶点铺平了道路。
World J Gastroenterol. 2014-5-21
Open Access Maced J Med Sci. 2016-12-15
Cureus. 2022-5-27
Discoveries (Craiova). 2018-12-31
Asian Pac J Cancer Prev. 2024-2-1
Ann Med Surg (Lond). 2023-4-17
Cancers (Basel). 2021-9-7
Int J Mol Sci. 2021-6-24
Cancers (Basel). 2020-2-10
Exp Hematol Oncol. 2019-10-11
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