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Beclin 1 和 HER2 在结直肠癌中的作用：一项免疫组织化学研究。

The Role of Beclin 1 and HER2 in Colorectal Carcinoma; An Immunohistochemical Study.

机构信息

Department of Pathology, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt.

出版信息

Asian Pac J Cancer Prev. 2024 Feb 1;25(2):617-626. doi: 10.31557/APJCP.2024.25.2.617.

DOI:10.31557/APJCP.2024.25.2.617
PMID:38415549
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11077107/
Abstract

OBJECTIVE

This study aimed to evaluate the expression of Beclin 1 and HER2 proteins using immunohistochemistry in CRC tissues compared to colonic adenoma, and to investigate the correlation of their expression with clinicopathological parameters and survival outcomes in CRC patients.

METHODS

The study utilized paraffin-embedded blocks from 17 colonic adenoma and 81 CRC cases. Immunohistochemical analysis was performed to assess the expression of Beclin 1 and HER2 proteins.

RESULTS

The cytoplasmic expression of Beclin 1 was significantly higher in CRC tissues compared to adenoma specimens (P=0.051). High Beclin 1 expression was significantly associated with distal colon location (P=0.028). High HER2 cytoplasmic expression was significantly associated with vascular invasion (P=0.05), perineural invasion (P=0.03), and shorter overall survival (P=0.035).

CONCLUSIONS

The findings suggest that Beclin 1 plays a role in colorectal carcinogenesis, with higher expression observed in CRC cases compared to adenoma cases.  Furthermore, HER2 carries poor prognostic impact in CRC cases.

摘要

目的

本研究旨在通过免疫组织化学方法比较结直肠腺瘤与结直肠癌组织中 Beclin 1 和 HER2 蛋白的表达，并探讨其表达与结直肠癌患者临床病理参数和生存结局的相关性。

方法

本研究使用了 17 例结肠腺瘤和 81 例结直肠癌病例的石蜡包埋块。采用免疫组织化学分析评估 Beclin 1 和 HER2 蛋白的表达。

结果

CRC 组织中 Beclin 1 的细胞质表达明显高于腺瘤标本（P=0.051）。高 Beclin 1 表达与结肠远端位置显著相关（P=0.028）。HER2 细胞质高表达与血管侵犯（P=0.05）、神经周围侵犯（P=0.03）和总生存时间较短显著相关（P=0.035）。

结论

这些发现表明 Beclin 1 在结直肠肿瘤发生中起作用，与腺瘤相比，CRC 中观察到更高的表达。此外，HER2 在 CRC 中具有不良的预后影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25d6/11077107/80daeb9b5093/APJCP-25-617-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25d6/11077107/a180e77bef84/APJCP-25-617-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25d6/11077107/a74e4261f378/APJCP-25-617-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25d6/11077107/80daeb9b5093/APJCP-25-617-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25d6/11077107/a180e77bef84/APJCP-25-617-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25d6/11077107/a74e4261f378/APJCP-25-617-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25d6/11077107/80daeb9b5093/APJCP-25-617-g003.jpg

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Human Epidermal Growth Factor Receptor 2 (HER2) Expression in Colorectal Carcinoma: A Potential Area of Focus for Future Diagnostics.人表皮生长因子受体2（HER2）在结直肠癌中的表达：未来诊断的一个潜在重点领域。
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Tackling Refractory Metastatic Colorectal Cancer: Future Perspectives.
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HER2 overexpression is a putative diagnostic and prognostic biomarker for late-stage colorectal cancer in North African patients.HER2 过表达被认为是北非晚期结直肠癌的一种诊断和预后生物标志物。
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Prognostic Value of Autophagy, Microsatellite Instability, and Mutations in Colorectal Cancer.自噬、微卫星不稳定性及突变在结直肠癌中的预后价值
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