Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, 200233, China.
BMC Endocr Disord. 2022 Apr 5;22(1):91. doi: 10.1186/s12902-022-01002-w.
Sex hormones are strongly linked to the occurrence and development of diabetes, and influence glycated hemoglobin (HbA) levels in diabetic population; but, the relationship between sex hormones and HbA in non-diabetic population remains unknown. This study aimed to explore the extent of influence of sex hormones on HbA levels in non-diabetic population.
A total of 1409 non-diabetic subjects, including 601 men and 808 postmenopausal women were recruited from Shanghai community. HbA was detected using high performance liquid chromatography, and hemoglobin level was determined by sodium lauryl sulfate colorimetry. Serum estradiol (E), total testosterone (TT), and sex hormone binding globulin (SHBG) were measured by chemiluminescent microparticle immunoassays.
The level of HbA was 5.6 (5.4-5.9) % in all subjects, with 5.6 (5.4-5.8) % in men and 5.7 (5.5-5.9) % in postmenopausal women. After adjusting for age, body mass index (BMI), and hemoglobin, E was positively correlated with HbA in men (r = 0.122, P = .003), and SHBG was inversely correlated with HbA (r = - 0.125, P < .001) in women. Other hormones were not correlated with HbA (all P > .05). Multivariate linear regression analysis showed that, except for traditional factors, such as age, hemoglobin, and BMI, E was another determinant of HbA (standardized β = 0.137, P = .003) in men; besides, in women, SHBG was another determinant of HbA (standardized β = - 0.178, P < .001), except for age and systolic blood pressure.
After controlling for confounding factors, two sex hormones, as E and SHBG could influence HbA levels in non-diabetic population.
性激素与糖尿病的发生和发展密切相关，并影响糖尿病患者的糖化血红蛋白（HbA）水平；然而，非糖尿病患者中性激素与 HbA 的关系尚不清楚。本研究旨在探讨性激素对非糖尿病人群 HbA 水平的影响程度。
共招募 1409 名非糖尿病受试者，包括 601 名男性和 808 名绝经后女性，来自上海社区。采用高效液相色谱法检测 HbA，采用十二烷基硫酸钠比色法测定血红蛋白水平。采用化学发光微粒子免疫分析法检测血清雌二醇（E）、总睾酮（TT）和性激素结合球蛋白（SHBG）。
所有受试者的 HbA 水平为 5.6（5.4-5.9）%，男性为 5.6（5.4-5.8）%，绝经后女性为 5.7（5.5-5.9）%。在校正年龄、体重指数（BMI）和血红蛋白后，E 与男性 HbA 呈正相关（r=0.122，P=0.003），SHBG 与女性 HbA 呈负相关（r=-0.125，P<0.001）。其他激素与 HbA 无相关性（均 P>0.05）。多元线性回归分析显示，除年龄、血红蛋白和 BMI 等传统因素外，E 是男性 HbA 的另一个决定因素（标准化β=0.137，P=0.003）；此外，除年龄和收缩压外，SHBG 是女性 HbA 的另一个决定因素（标准化β=-0.178，P<0.001）。
在控制混杂因素后，两种性激素，即 E 和 SHBG，可能影响非糖尿病人群的 HbA 水平。
