Department of Neurology, Second Faculty of Medicine, Motol Epilepsy Center, Charles University, Motol University Hospital, Prague, Czech Republic.
Memory Clinic, Department of Neurology, Second Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czech Republic.
Alzheimers Res Ther. 2022 Apr 5;14(1):50. doi: 10.1186/s13195-022-00989-7.
The ability to understand emotions is often disturbed in patients with cognitive impairments. Right temporal lobe structures play a crucial role in emotional processing, especially the amygdala, temporal pole (TP), superior temporal sulcus (STS), and anterior cingulate (AC). Those regions are affected in early stages of Alzheimer´s disease (AD). The aim of our study was to evaluate emotional prosody recognition (EPR) in participants with amnestic mild cognitive impairment (aMCI) due to AD, AD dementia patients, and cognitively healthy controls and to measure volumes or thickness of the brain structures involved in this process. In addition, we correlated EPR score to cognitive impairment as measured by MMSE. The receiver operating characteristic (ROC) analysis was used to assess the ability of EPR tests to differentiate the control group from the aMCI and dementia groups.
Eighty-nine participants from the Czech Brain Aging Study: 43 aMCI due to AD, 36 AD dementia, and 23 controls, underwent Prosody Emotional Recognition Test. This experimental test included the playback of 25 sentences with neutral meaning each recorded with different emotional prosody (happiness, sadness, fear, disgust, anger). Volume of the amygdala and thickness of the TP, STS, and rostral and caudal parts of AC (RAC and CAC) were measured using FreeSurfer algorithm software. ANCOVA was used to evaluate EPR score differences. ROC analysis was used to assess the ability of EPR test to differentiate the control group from the aMCI and dementia groups. The Pearson's correlation coefficients were calculated to explore relationships between EPR scores, structural brain measures, and MMSE.
EPR was lower in the dementia and aMCI groups compared with controls. EPR total score had high sensitivity in distinguishing between not only controls and patients, but also controls and aMCI, controls and dementia, and aMCI and dementia. EPR decreased with disease severity as it correlated with MMSE. There was a significant positive correlation of EPR and thickness of the right TP, STS, and bilateral RAC.
EPR is impaired in AD dementia and aMCI due to AD. These data suggest that the broad range of AD symptoms may include specific deficits in the emotional sphere which further complicate the patient's quality of life.
理解情绪的能力在认知障碍患者中经常受到干扰。右颞叶结构在情绪处理中起着至关重要的作用，特别是杏仁核、颞极（TP）、颞上沟（STS）和前扣带（AC）。这些区域在阿尔茨海默病（AD）的早期阶段受到影响。我们的研究目的是评估由于 AD 导致的遗忘型轻度认知障碍（aMCI）、AD 痴呆患者和认知健康对照者的情绪韵律识别（EPR），并测量参与该过程的脑结构的体积或厚度。此外，我们将 EPR 评分与 MMSE 测量的认知障碍相关联。使用接收者操作特征（ROC）分析来评估 EPR 测试区分对照组与 aMCI 和痴呆组的能力。
捷克大脑衰老研究中的 89 名参与者：43 名由于 AD 导致的 aMCI、36 名 AD 痴呆和 23 名对照，接受了韵律情感识别测试。这个实验测试包括播放 25 个具有中性意义的句子，每个句子都带有不同的情绪韵律（快乐、悲伤、恐惧、厌恶、愤怒）。使用 FreeSurfer 算法软件测量杏仁核的体积和 TP、STS 以及前扣带的 rostral 和 caudal 部分（RAC 和 CAC）的厚度。使用协方差分析（ANCOVA）评估 EPR 评分差异。ROC 分析用于评估 EPR 测试区分对照组与 aMCI 和痴呆组的能力。计算 Pearson 相关系数以探索 EPR 评分、结构脑测量值和 MMSE 之间的关系。
痴呆症和 aMCI 组的 EPR 评分低于对照组。EPR 总分在区分不仅是对照组和患者，而且是对照组和 aMCI、对照组和痴呆症以及 aMCI 和痴呆症之间具有很高的敏感性。EPR 随着疾病严重程度的增加而降低，因为它与 MMSE 相关。EPR 与右侧 TP、STS 和双侧 RAC 的厚度呈显著正相关。
AD 痴呆症和由于 AD 导致的 aMCI 中 EPR 受损。这些数据表明，广泛的 AD 症状可能包括情感领域的特定缺陷，这进一步使患者的生活质量复杂化。
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