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FTO stabilizes MIS12 and counteracts senescence.

作者信息

Zhang Sheng, Wu Zeming, Shi Yue, Wang Si, Ren Jie, Yu Zihui, Huang Daoyuan, Yan Kaowen, He Yifang, Liu Xiaoqian, Ji Qianzhao, Liu Beibei, Liu Zunpeng, Qu Jing, Liu Guang-Hui, Ci Weimin, Wang Xiaoqun, Zhang Weiqi

机构信息

State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

出版信息

Protein Cell. 2022 Dec;13(12):954-960. doi: 10.1007/s13238-022-00914-6. Epub 2022 Apr 6.

DOI:10.1007/s13238-022-00914-6
PMID:35384602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9243202/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a31/9243202/a9b2691a3786/13238_2022_914_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a31/9243202/f05f4888fe04/13238_2022_914_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a31/9243202/a9b2691a3786/13238_2022_914_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a31/9243202/f05f4888fe04/13238_2022_914_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a31/9243202/a9b2691a3786/13238_2022_914_Fig2_HTML.jpg

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1
FTO stabilizes MIS12 and counteracts senescence.FTO可稳定MIS12并对抗细胞衰老。
Protein Cell. 2022 Dec;13(12):954-960. doi: 10.1007/s13238-022-00914-6. Epub 2022 Apr 6.
2
Yeast screening system reveals the inhibitory mechanism of cancer cell proliferation by benzyl isothiocyanate through down-regulation of Mis12.酵母筛选系统揭示了苄基异硫氰酸酯通过下调 Mis12 抑制癌细胞增殖的作用机制。
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3
Hsp90-Sgt1 and Skp1 target human Mis12 complexes to ensure efficient formation of kinetochore-microtubule binding sites.热休克蛋白 90-Sgt1 和 Skp1 靶向人 Mis12 复合物，以确保动粒-微管结合位点的有效形成。
J Cell Biol. 2010 Apr 19;189(2):261-74. doi: 10.1083/jcb.200910036.
4
A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1.一个保守的Mis12着丝粒复合体与异染色质HP1和外着丝粒蛋白Zwint-1相关联。
Nat Cell Biol. 2004 Nov;6(11):1135-41. doi: 10.1038/ncb1187. Epub 2004 Oct 24.
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Drosophila Mis12 complex acts as a single functional unit essential for anaphase chromosome movement and a robust spindle assembly checkpoint.果蝇 Mis12 复合物作为一个单一的功能单位，对于后期染色体运动和强大的纺锤体组装检查点是必不可少的。
Genetics. 2011 Jan;187(1):131-40. doi: 10.1534/genetics.110.119628. Epub 2010 Oct 26.
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Mis12 controls cyclin B1 stabilization via Cdc14B-mediated APC/C regulation during meiotic G2/M transition in mouse oocytes.Mis12 通过 Cdc14B 介导的 APC/C 调控控制减数分裂 G2/M 转换期间小鼠卵母细胞中环化蛋白 B1 的稳定性。
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Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1-Mad2.Cep57是一种与Mis12相互作用的动粒蛋白，参与Mad1-Mad2在动粒上的靶向定位。
Nat Commun. 2016 Jan 8;7:10151. doi: 10.1038/ncomms10151.
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CENP-C is a structural platform for kinetochore assembly.着丝粒蛋白 C 是着丝粒装配的结构平台。
Curr Biol. 2011 Mar 8;21(5):399-405. doi: 10.1016/j.cub.2011.02.005. Epub 2011 Feb 25.
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The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation.人源Mis12复合体是动粒组装和正确染色体分离所必需的。
J Cell Biol. 2006 Apr 10;173(1):9-17. doi: 10.1083/jcb.200509158. Epub 2006 Apr 3.
10
Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment.Plk1 在着丝粒处将 Sgt1 磷酸化，以促进动粒-微管的适时连接。
Mol Cell Biol. 2012 Oct;32(19):4053-67. doi: 10.1128/MCB.00516-12. Epub 2012 Aug 6.

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本文引用的文献

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Low-dose chloroquine treatment extends the lifespan of aged rats.低剂量氯喹治疗可延长老年大鼠的寿命。
Protein Cell. 2022 Jun;13(6):454-461. doi: 10.1007/s13238-021-00903-1.
2
Large-scale chemical screen identifies Gallic acid as a geroprotector for human stem cells.大规模化学筛选确定没食子酸是人类干细胞的老年保护剂。
Protein Cell. 2022 Jul;13(7):532-539. doi: 10.1007/s13238-021-00872-5. Epub 2021 Sep 20.
3
mAm-seq reveals the dynamic mAm methylation in the human transcriptome.mAm-seq 揭示了人类转录组中动态的 mAm 甲基化。
Life Med. 2022 Nov 22;1(3):307-318. doi: 10.1093/lifemedi/lnac054. eCollection 2022 Dec.
4
Dynamic multilayered control of mA RNA demethylase activity.动态多层控制 mA RNA 去甲基化酶活性。
Proc Natl Acad Sci U S A. 2024 Nov 12;121(46):e2317847121. doi: 10.1073/pnas.2317847121. Epub 2024 Nov 4.
5
Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases.染色质和基因组不稳定性在细胞衰老中的作用及其与衰老和相关疾病的关系。
Nat Rev Mol Cell Biol. 2024 Dec;25(12):979-1000. doi: 10.1038/s41580-024-00775-3. Epub 2024 Oct 3.
6
CRISPR screening uncovers nucleolar RPL22 as a heterochromatin destabilizer and senescence driver.CRISPR 筛选揭示核仁 RPL22 作为异染色质稳定剂和衰老驱动因子。
Nucleic Acids Res. 2024 Oct 28;52(19):11481-11499. doi: 10.1093/nar/gkae740.
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FTO deficiency in older livers exacerbates ferroptosis during ischaemia/reperfusion injury by upregulating ACSL4 and TFRC.FTO 缺陷在老年肝脏中通过上调 ACSL4 和 TFRC 加剧缺血/再灌注损伤中的铁死亡。
Nat Commun. 2024 Jun 4;15(1):4760. doi: 10.1038/s41467-024-49202-3.
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FTO Positively Regulates Odontoblastic Differentiation via SMOC2 in Human Stem Cells from the Apical Papilla under Inflammatory Microenvironment.FTO 通过 SMOC2 正向调控炎症微环境下牙髓干细胞的成牙本质分化。
Int J Mol Sci. 2024 Apr 5;25(7):4045. doi: 10.3390/ijms25074045.
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Multimodal Omics Approaches to Aging and Age-Related Diseases.衰老及年龄相关疾病的多组学研究方法
Phenomics. 2024 Feb 24;4(1):56-71. doi: 10.1007/s43657-023-00125-x. eCollection 2024 Feb.
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J Inflamm Res. 2024 Mar 20;17:1857-1871. doi: 10.2147/JIR.S447379. eCollection 2024.
Nat Commun. 2021 Aug 6;12(1):4778. doi: 10.1038/s41467-021-25105-5.
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The m6A mRNA demethylase FTO in granulosa cells retards FOS-dependent ovarian aging.卵泡细胞中的 m6A mRNA 去甲基化酶 FTO 延缓了 FOS 依赖的卵巢衰老。
Cell Death Dis. 2021 Jul 27;12(8):744. doi: 10.1038/s41419-021-04016-9.
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Generation of a FTO gene knockout human embryonic stem cell line using CRISPR/Cas9 editing.利用 CRISPR/Cas9 编辑技术生成 FTO 基因敲除人胚胎干细胞系。
Stem Cell Res. 2021 May;53:102362. doi: 10.1016/j.scr.2021.102362. Epub 2021 Apr 22.
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FTO regulates myoblast proliferation by controlling CCND1 expression in an mA-YTHDF2-dependent manner.FTO 通过控制 mA-YTHDF2 依赖的 CCND1 表达来调节成肌细胞增殖。
Exp Cell Res. 2021 Apr 15;401(2):112524. doi: 10.1016/j.yexcr.2021.112524. Epub 2021 Feb 27.
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METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA.METTL3 通过依赖 m6A 的 MIS12 mRNA 稳定性来对抗早衰。
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Signal Transduct Target Ther. 2020 Jul 28;5(1):130. doi: 10.1038/s41392-020-00234-3.
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Cancer Cell. 2020 Mar 16;37(3):270-288. doi: 10.1016/j.ccell.2020.02.004.