Faculty of Materials and Metallurgical Engineering, Semnan University, Semnan, Iran.
Department of Food Nanotechnology, Research Institute of Food Science and Technology, Mashhad, Iran.
J Microencapsul. 2022 May;39(3):226-238. doi: 10.1080/02652048.2022.2060360. Epub 2022 Apr 9.
In this study, chitosan-coated niosome (ChN) was utilised for bioavailability enhancement of curcumin (Cn) and boswellic acids (BAs). The bare niosome (BN) was prepared by the heating method and optimised by using the mixture design procedure. Physicochemical stability, as well as the in vitro release, and bioavailability of Cn and BAs in BN and ChN were studied. The optimised BN had a mean diameter of 70.00 ± 0.21 nm and surface charge of -31.00 ± 0.25 mv, which changed to 60.01 ± 0.20 nm and +40.00 ± 0, respectively, in ChN. digestion study revealed chitosan layer augmented the bioavailability of Cn and BAs to 79.02 ± 0.13 and 81 ± 0.10, respectively. The chitosan layer obviously improved the physical stability of Cn and BA in the niosome vehicle, by means of vesicle size, zeta potential, and encapsulation efficiency. The ChN was considered to be promising delivery system for increasing the bioavailability of Cn and BAs.
在这项研究中，壳聚糖包覆的尼奥斯ome（ChN）被用于提高姜黄素（Cn）和乳香酸（BAs）的生物利用度。裸尼奥斯ome（BN）通过加热法制备，并通过使用混合设计程序进行优化。研究了 BN 和 ChN 中 Cn 和 BAs 的物理化学稳定性、体外释放和生物利用度。优化后的 BN 的平均直径为 70.00 ± 0.21nm，表面电荷为-31.00 ± 0.25mV，在 ChN 中分别变为 60.01 ± 0.20nm 和+40.00 ± 0。消化研究表明，壳聚糖层将 Cn 和 BAs 的生物利用度分别提高到 79.02 ± 0.13 和 81 ± 0.10。壳聚糖层通过囊泡大小、Zeta 电位和包封效率明显提高了 Cn 和 BA 在尼奥斯ome 载体中的物理稳定性。ChN 被认为是一种有前途的递送系统，可提高 Cn 和 BAs 的生物利用度。
