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An outbreak investigation of scrub typhus in Nepal: confirmation of local transmission.尼泊尔恙虫病暴发调查:确认本地传播。
BMC Infect Dis. 2021 Feb 18;21(1):193. doi: 10.1186/s12879-021-05866-6.
2
The PROCESS 2020 Guideline: Updating Consensus Preferred Reporting Of CasESeries in Surgery (PROCESS) Guidelines.《2020年手术病例系列报告共识优先报告指南(PROCESS)更新指南》
Int J Surg. 2020 Dec;84:231-235. doi: 10.1016/j.ijsu.2020.11.005. Epub 2020 Nov 12.
3
Diagnostic performance of serological tests to detect antibodies against acute scrub typhus infection in central India.印度中部地区检测抗急性恙虫病感染抗体的血清学检测的诊断性能
Indian J Med Microbiol. 2018 Jan-Mar;36(1):108-112. doi: 10.4103/ijmm.IJMM_17_405.
4
A review of the global epidemiology of scrub typhus.恙虫病全球流行病学综述。
PLoS Negl Trop Dis. 2017 Nov 3;11(11):e0006062. doi: 10.1371/journal.pntd.0006062. eCollection 2017 Nov.
5
Eschar is associated with poor prognosis in scrub typhus.焦痂与恙虫病的预后不良相关。
Indian J Med Res. 2017 May;145(5):693-696. doi: 10.4103/ijmr.IJMR_1888_15.
6
Typhoid versus typhus fever in post-earthquake Nepal.尼泊尔地震后的伤寒与斑疹伤寒
Lancet Glob Health. 2016 Aug;4(8):e516-7. doi: 10.1016/S2214-109X(16)30094-8.
7
A Systematic Review of Mortality from Untreated Scrub Typhus (Orientia tsutsugamushi).未经治疗的恙虫病(恙虫东方体)死亡率的系统评价
PLoS Negl Trop Dis. 2015 Aug 14;9(8):e0003971. doi: 10.1371/journal.pntd.0003971. eCollection 2015.
8
Severe scrub typhus infection: Clinical features, diagnostic challenges and management.严重恙虫病感染:临床特征、诊断挑战与管理
World J Crit Care Med. 2015 Aug 4;4(3):244-50. doi: 10.5492/wjccm.v4.i3.244.
9
Clinical Manifestations and Complications of Scrub Typhus : A Hospital Based Study from North Eastern India.恙虫病的临床表现及并发症:一项来自印度东北部的医院研究
J Assoc Physicians India. 2014 Dec;62(12):19-23.
10
Diagnostic validation of selected serological tests for detecting scrub typhus.用于检测恙虫病的特定血清学检测方法的诊断验证
Microbiol Immunol. 2015 Jul;59(7):371-4. doi: 10.1111/1348-0421.12268.

尼泊尔一家初级卫生保健中心的恙虫病:病例系列

Scrub typhus in a primary health care center of Nepal: A case series.

作者信息

Gurung Shekhar, Karki Saurab, Pokharel Subashchandra, Bhatta Kishor

机构信息

Aaruchanaute Primary Health Care Center, Aarughat, Gorkha, Nepal.

Military Hospital Itahari, Sunsari, Nepal.

出版信息

Ann Med Surg (Lond). 2022 Mar 8;75:103490. doi: 10.1016/j.amsu.2022.103490. eCollection 2022 Mar.

DOI:10.1016/j.amsu.2022.103490
PMID:35386785
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8978104/
Abstract

INTRODUCTION

Scrub typhus is endemic in most parts of Southeast Asia including Nepal. Fever, rash, headache, myalgia, eschar are the common clinical features. Though endemic, scrub typhus is grossly underdiagnosed in our country due to the lack of diagnostic tools and non-specific presentation of the disease. Here we present a series of 23 cases of scrub typhus from a primary healthcare center of Nepal.

METHOD

This is a retrospective case series done among 23 patients diagnosed with scrub typhus and admitted to Aaruchanaute Primary health care center between August 15, 2021 to September 14, 2021. Epidemiological, clinical features and clinical outcomes of all the patients are described.

RESULTS

Among 23 patients admitted to the primary health care center,78% were of age group 20-60 with 47% male patients. Fever was reported by all patients followed by headache (65%), cough (43%) and eschar (8%). All patients were diagnosed by rapid diagnostic kit. 95% of patients had complete recovery whereas 1 patient was referred to a higher center due to complications he developed during the period of hospital stay.

CONCLUSION

We conclude that when a patient presents with fever and eschar, there should be a high index of suspicion for scrub typhus, though eschar may not be present in many of the cases. Early diagnosis and prompt treatment with antibiotics is the key as the disease entity shows a good response to treatment while preventing potentially fatal complications.

摘要

引言

恙虫病在包括尼泊尔在内的东南亚大部分地区流行。发热、皮疹、头痛、肌痛、焦痂是常见的临床特征。尽管恙虫病呈地方性流行,但由于缺乏诊断工具以及该病临床表现不具特异性,在我国其诊断严重不足。在此,我们展示了尼泊尔一家初级医疗中心的23例恙虫病病例。

方法

这是一项回顾性病例系列研究,研究对象为2021年8月15日至2021年9月14日期间被诊断为恙虫病并入住阿鲁查瑙特初级医疗中心的23例患者。描述了所有患者的流行病学、临床特征和临床结局。

结果

在入住初级医疗中心的23例患者中,78%为20至60岁年龄组,男性患者占47%。所有患者均有发热症状,其次是头痛(65%)、咳嗽(43%)和焦痂(8%)。所有患者均通过快速诊断试剂盒确诊。95%的患者完全康复,而1例患者因住院期间出现并发症被转诊至上级中心。

结论

我们得出结论,当患者出现发热和焦痂时,应高度怀疑恙虫病,尽管许多病例可能没有焦痂。早期诊断并及时使用抗生素治疗是关键,因为该疾病对治疗反应良好,同时可预防潜在的致命并发症。