Causal Gene Confusion: The Complicated Locus for Coronary Artery Disease.
作者信息
Gupta Rajat M
机构信息
Divisions of Genetics and Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA. Harvard Medical School, Boston, MA.
出版信息
Arterioscler Thromb Vasc Biol. 2022 May;42(5):610-612. doi: 10.1161/ATVBAHA.122.317539. Epub 2022 Apr 7.
Abstract
摘要
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Nat Genet. 2022 Dec;54(12):1803-1815. doi: 10.1038/s41588-022-01233-6. Epub 2022 Dec 6.
2
PHACTR-1 (Phosphatase and Actin Regulator 1) Deficiency in Either Endothelial or Smooth Muscle Cells Does Not Predispose Mice to Nonatherosclerotic Arteriopathies in 3 Transgenic Mice.在内皮细胞或平滑肌细胞中，PHACTR-1（磷酸酶和肌动蛋白调节因子1）缺乏不会使3种转基因小鼠易患非动脉粥样硬化性动脉病变。
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3
Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosis.巨噬细胞 PHACTR1 缺乏会损害吞噬作用并促进动脉粥样硬化斑块坏死。
J Clin Invest. 2021 Apr 15;131(8). doi: 10.1172/JCI145275.
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Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction.内皮素-1的基因失调与冠状动脉微血管功能障碍有关。
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