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Causal Gene Confusion: The Complicated Locus for Coronary Artery Disease.

作者信息

Gupta Rajat M

机构信息

Divisions of Genetics and Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA. Harvard Medical School, Boston, MA.

出版信息

Arterioscler Thromb Vasc Biol. 2022 May;42(5):610-612. doi: 10.1161/ATVBAHA.122.317539. Epub 2022 Apr 7.

DOI:10.1161/ATVBAHA.122.317539
PMID:35387481
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9050840/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2299/9050840/07ac9a8dbc0c/nihms-1786468-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2299/9050840/07ac9a8dbc0c/nihms-1786468-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2299/9050840/07ac9a8dbc0c/nihms-1786468-f0001.jpg

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本文引用的文献

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Nat Genet. 2022 Dec;54(12):1803-1815. doi: 10.1038/s41588-022-01233-6. Epub 2022 Dec 6.
2
PHACTR-1 (Phosphatase and Actin Regulator 1) Deficiency in Either Endothelial or Smooth Muscle Cells Does Not Predispose Mice to Nonatherosclerotic Arteriopathies in 3 Transgenic Mice.在内皮细胞或平滑肌细胞中，PHACTR-1（磷酸酶和肌动蛋白调节因子1）缺乏不会使3种转基因小鼠易患非动脉粥样硬化性动脉病变。
Arterioscler Thromb Vasc Biol. 2022 May;42(5):597-609. doi: 10.1161/ATVBAHA.122.317431. Epub 2022 Apr 7.
3
当前和未来针对心血管疾病内皮素途径的靶向策略。
Nat Cardiovasc Res. 2023 Nov;2(11):972-990. doi: 10.1038/s44161-023-00347-2. Epub 2023 Nov 2.
4
Enhancing prediction accuracy of coronary artery disease through machine learning-driven genomic variant selection.通过机器学习驱动的基因组变异选择提高冠状动脉疾病预测准确性。
J Transl Med. 2024 Apr 16;22(1):356. doi: 10.1186/s12967-024-05090-1.
5
Prediction of causal genes at GWAS loci with pleiotropic gene regulatory effects using sets of correlated instrumental variables.利用相关工具变量集对具有多效基因调控效应的全基因组关联研究（GWAS）位点的因果基因进行预测。
ArXiv. 2024 Sep 20:arXiv:2401.06261v3.
6
The Role of Endothelial Cells in Atherosclerosis: Insights from Genetic Association Studies.内皮细胞在动脉粥样硬化中的作用：遗传关联研究的新见解。
Am J Pathol. 2024 Apr;194(4):499-509. doi: 10.1016/j.ajpath.2023.09.012. Epub 2023 Oct 10.
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