Department of Endocrinology, Haining People's Hospital, Haining 314400, Zhejiang, China.
J Healthc Eng. 2022 Mar 28;2022:9001881. doi: 10.1155/2022/9001881. eCollection 2022.
To investigate the effect of levothyroxine sodium tablets (L-T4) on pregnancy outcome and offspring development quotient in patients with subclinical hypothyroidism (SCH) during pregnancy. Pregnant women with gestational age less than 12 weeks who underwent the first prenatal examination in our hospital from January 2019 to December 2019 were prospectively selected as subjects. According to the level of thyroid hormone in pregnant women, they were divided into the treatment group (n = 63) and received L-T4 treatment, untreated group (n = 64), and control group (n = 54). Three groups of pregnancy outcomes, children's physical development, and the development of offspring were compared at when one full year of life.
After treatment, the contrast difference of the three groups about abortion and gestational diabetes mellitus (GDM) was statistically significant ( < 0.05). The abortion rate and gestational diabetes mellitus (GDM) in the untreated group were higher than those in the control group ( < 0.05). The contrast difference of the treatment group and control group about abortion and gestational diabetes mellitus (GDM) is not statistically significant ( > 0.05); The contrast difference of the three groups about a filial generation at birth and one-year-old body length is not statistically significant ( > 0.05). The contrast difference between the three groups of individual children who are one-year old having the individual action energy, material ability, speech ability, and human ability is statistically significant ( < 0.05). One-year-old developmental quotient (DQ) of the treatment group and control group was higher than that of the untreated group ( < 0.05); the Pearson correlation analysis showed that the treatment group TSH levels have no correlation between the offspring developmental quotient (DQ) level of one-year-old children ( > 0.05).
Levothyroxine sodium tablets (L-T4) can not only improve the pregnancy outcome of patients with SCH during pregnancy but also play a positive role in improving the neurointellectual development of their offspring.
探讨左旋甲状腺素钠片（L-T4）对妊娠合并亚临床甲状腺功能减退症（SCH）患者妊娠结局及子代发育商的影响。
选择 2019 年 1 月至 2019 年 12 月在我院首次产前检查且孕周<12 周的孕妇为研究对象，根据孕妇甲状腺激素水平分为治疗组（n=63）和未治疗组（n=64），同时选取同期健康孕妇 54 例作为对照组。比较三组妊娠结局、子代体格发育及发育商。
治疗后，三组流产率、妊娠期糖尿病（GDM）发生率比较差异有统计学意义（<0.05）；未治疗组流产率、GDM 发生率高于对照组（<0.05）；治疗组与对照组比较差异无统计学意义（>0.05）；三组间出生时一代、1 岁时身长比较差异无统计学意义（>0.05）；三组间 1 岁时个体动作能量、物质能力、言语能力、人类能力个体差异比较差异有统计学意义（<0.05）；治疗组、对照组 1 岁时发育商（DQ）高于未治疗组（<0.05）；Pearson 相关性分析显示，治疗组 TSH 水平与 1 岁子代发育商（DQ）水平无相关性（>0.05）。
左旋甲状腺素钠片（L-T4）不仅可以改善妊娠合并 SCH 患者的妊娠结局，而且对改善其后代的神经智力发育也具有积极作用。
