青年人群中 TSH 水平与认知功能的关系：人类连接组计划数据分析。

Relationship Between TSH Levels and Cognition in the Young Adult: An Analysis of the Human Connectome Project Data.

机构信息

Division of Endocrinology, Diabetes, & Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

出版信息

J Clin Endocrinol Metab. 2022 Jun 16;107(7):1897-1905. doi: 10.1210/clinem/dgac189.

DOI:10.1210/clinem/dgac189

PMID:35389477

Abstract

CONTEXT

The nature of the relationship between serum thyrotropin (TSH) levels and higher cognitive abilities is unclear, especially within the normal reference range and in the younger population.

OBJECTIVE

To assess the relationship between serum TSH levels and mental health and sleep quality parameters (fluid intelligence [Gf], MMSE (Mini-Mental State Examination), depression scores, and, finally, Pittsburgh Sleep Quality Index (PSQI) scores (working memory, processing speed, and executive function) in young adults.

METHODS

This was a retrospective analysis of the data from the Human Connectome Project (HCP). The HCP consortium is seeking to map human brain circuits systematically and identify their relationship to behavior in healthy adults. Included were 391 female and 412 male healthy participants aged 22-35 years at the time of the screening interview. We excluded persons with serum TSH levels outside the reference range (0.4-4.5 mU/L). TSH was transformed logarithmically (log TSH). All the key variables were normalized and then linear regression analysis was performed to assess the relationship between log TSH as a cofactor and Gf as the dependent variable. Finally, a machine learning method, random forest regression, predicted Gf from the dependent variables (including alcohol and tobacco use). The main outcome was normalized Gf (nGf) and Gf scores.

RESULTS

Log TSH was a significant co-predictor of nGF in females (β = 0.31(±0.1), P < .01) but not in males. Random forest analysis showed that the model(s) had a better predictive value for females (r = 0.39, mean absolute error [MAE] = 0.81) than males (r = 0.24, MAE = 0.77).

CONCLUSION

Higher serum TSH levels might be associated with higher Gf scores in young women.

摘要

背景

血清促甲状腺激素（TSH）水平与较高认知能力之间的关系尚不清楚，尤其是在正常参考范围内和年轻人群中。

目的

评估年轻成年人的血清 TSH 水平与心理健康和睡眠质量参数（流体智力[Gf]、简易精神状态检查（MMSE）、抑郁评分，最后是匹兹堡睡眠质量指数（PSQI）评分（工作记忆、处理速度和执行功能）之间的关系。

方法

这是对人类连接组计划（HCP）数据的回顾性分析。HCP 联合体正在寻求系统地绘制人类大脑回路图并识别它们与健康成年人行为之间的关系。纳入的是 391 名女性和 412 名年龄在 22-35 岁之间的健康参与者。我们排除了血清 TSH 水平超出参考范围（0.4-4.5 mU/L）的人。TSH 被转化为对数（log TSH）。所有关键变量都被归一化，然后进行线性回归分析，以评估作为协变量的 log TSH 与作为因变量的 Gf 之间的关系。最后，使用机器学习方法随机森林回归，从依赖变量（包括酒精和烟草使用）预测 Gf。主要结果是归一化 Gf（nGf）和 Gf 分数。