Barcellini W, Meroni P L, Lazzarin A, Sguotti C, Parravicini C, Borghi M O, Brucato A, Moroni M, Sirianni M C, Aiuti F
Boll Ist Sieroter Milan. 1986;65(4):269-76.
The persistent generalized lymphadenopathy (PGL) in drug addicts displays the same immunological abnormalities previously found in homosexual and haemophiliac men with PGL: impaired in vivo and in vitro T cell functions, inverted T4/T8 ratio in blood and B cell abnormalities. The peripheral blood B-lymphocytes, in fact, show a reduced in vitro immunoglobulin synthesis after pokeweed mitogen and Staphylococcus aureus activation, with an increased spontaneous IgG secretion. In the lymph node biopsies, the immuno-histological studies reveal an infiltration of OKT8 positive cells in the germinal centers, a depletion of OKT4 positive lymphocytes slighter than in the blood and an explosive follicular hyperplasia with a striking destruction of the dendritic reticulum cell framework. This latter finding, together with the high levels of serum IgG and the presence of preactivated B cells in the blood, seems to be consistent with the presence of an in vivo polyclonal B cell activation. A high incidence of anti-HTLV III antibodies was also found in the PGL drug addicts. The significance of these findings is discussed in this report.
吸毒者的持续性全身性淋巴结病（PGL）表现出与先前在患有PGL的同性恋者和血友病男性中发现的相同免疫异常：体内和体外T细胞功能受损、血液中T4/T8比值倒置以及B细胞异常。事实上，外周血B淋巴细胞在美洲商陆有丝分裂原和金黄色葡萄球菌激活后，体外免疫球蛋白合成减少，而自发性IgG分泌增加。在淋巴结活检中，免疫组织学研究显示生发中心有OKT8阳性细胞浸润，OKT4阳性淋巴细胞耗竭程度比血液中轻，以及滤泡性增生伴树突状网状细胞框架显著破坏。后一发现，连同血清IgG水平升高和血液中预激活B细胞的存在，似乎与体内多克隆B细胞激活的存在一致。在患有PGL的吸毒者中还发现抗HTLV III抗体的高发生率。本报告讨论了这些发现的意义。
