Vera-Sempere G, Vera-Sempere F J, Guix-García J
Departamento de Medicina, Hospital Clínico Universitario, Valencia.
An Med Interna. 1990 Dec;7(12):621-6.
Of a total of 41 VIH positive patients, parenteral drug addicts, with persistent generalized lymphadenopathy syndrome, we performed 43 lymph-node biopsies. In two sequential biopsies, 2 and 12 months respectively after the first biopsy, were carried-out. After a clinical follow-up (ranging between 4-28 months) 12 patients (24.3%) were qualified as SIDA cases according to CDC-1987 criteria. Lymph-node biopsy was of diagnostic or prognostic value in 16.27% and in 6.97% respectively. Upon comparing histological types and peripheral lymphocyte subsets it was demonstrated how the forms of major morphological deterioration tend to associate with a lower number of OKT4+ lymphocytes and a lower relation OKT4+/OKT8+.
在总共41例患有持续性全身性淋巴结病综合征的静脉注射药物成瘾的艾滋病毒阳性患者中，我们进行了43次淋巴结活检。在首次活检后的2个月和12个月分别进行了两次连续活检。经过4至28个月的临床随访，根据1987年疾病控制中心（CDC）的标准，有12例患者（24.3%）被判定为患艾滋病相关综合征（SIDA）病例。淋巴结活检分别在16.27%和6.97%的病例中具有诊断或预后价值。在比较组织学类型和外周淋巴细胞亚群时发现，主要形态学恶化形式往往与较低数量的OKT4 +淋巴细胞以及较低的OKT4 + / OKT8 +比值相关。
