Kamali Ghazal, Nassiri Nariman, Rahmani Khaled
School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI, USA.
Saudi J Ophthalmol. 2022 Feb 18;35(2):112-116. doi: 10.4103/1319-4534.337861. eCollection 2021 Apr-Jun.
Trochleitis has been recognized as one of the causes of eye pain and migraine headaches. This study attempts to investigate the effect of ibuprofen on reducing eye pain and migraine headaches caused by trochleitis.
In this before-after clinical trial, out of 1100 clinically examined patients with eye pain and migraine symptoms, 33 patients were diagnosed with having trochleitis and trochleodynia confirmed by orbital magnetic resonance imaging images. Ibuprofen (400 mg/6-8 h) was prescribed to the subjects for 15-30 days. The main outcomes were a reduction in tenderness and pain that were evaluated 2 weeks, a month, and 6 months after the prescription. The data were analyzed by STATA (version 14) and using Wilcoxon and McNemar tests.
The results revealed that 28 of the subjects (84.8%) experienced a significant reduction in tenderness 2 weeks after undergoing the treatment ( < 0.001). Standard deviation and average of headache scores before and after the treatment were 7.85 ± 1.75 and 0.64 ± 0.61 based on the visual analog scale. The difference between the pain scores before and after the treatment was statistically significant ( < 0.001). Clinical symptoms such as induration ( < 0.001), photophobia ( < 0.001), upward gaze ( < 0.001), and pain after reading ( < 0.001) were reduced significantly. Six months after the treatment, none of the mentioned symptoms was reported by the subjects.
The findings revealed that noninvasive treatment (ibuprofen) has reduced eye pain, tenderness, and migraine headaches caused by trochleitis. What is important to mention is that trochleitis should be diagnosed properly.
滑车炎已被确认为眼痛和偏头痛的病因之一。本研究旨在探讨布洛芬对减轻滑车炎所致眼痛和偏头痛的效果。
在这项前后对照临床试验中，1100名接受临床检查的眼痛和偏头痛症状患者中，33例经眼眶磁共振成像确诊为滑车炎和滑车神经痛。给予受试者布洛芬（400毫克/6 - 8小时），疗程为15 - 30天。主要观察指标为压痛和疼痛减轻情况，在用药后2周、1个月和6个月进行评估。数据采用STATA（版本14）进行分析，并使用Wilcoxon和McNemar检验。
结果显示，28名受试者（84.8%）在治疗2周后压痛显著减轻（<0.001）。根据视觉模拟量表，治疗前后头痛评分的标准差和平均值分别为7.85±1.75和0.64±0.61。治疗前后疼痛评分差异具有统计学意义（<0.001）。硬结（<0.001）、畏光（<0.001）、上视（<0.001）和阅读后疼痛（<0.001）等临床症状显著减轻。治疗6个月后，受试者均未报告上述症状。
研究结果表明，无创治疗（布洛芬）可减轻滑车炎所致的眼痛、压痛和偏头痛。需要提及的是，应正确诊断滑车炎。
