人白细胞糖蛋白Mo1的N端序列：跨物种保守性及与血小板IIb/IIIa的同源性
N-terminal sequence of human leukocyte glycoprotein Mo1: conservation across species and homology to platelet IIb/IIIa.
作者信息
Pierce M W, Remold-O'Donnell E, Todd R F, Arnaout M A
出版信息
Biochim Biophys Acta. 1986 Dec 12;874(3):368-71. doi: 10.1016/0167-4838(86)90037-3.
PMID:3539202
Abstract
Mo1 and gp160-gp93 are two surface membrane glycoprotein heterodimers present on granulocytes and monocytes derived from humans and guinea pigs, respectively. We purified both antigens and found that their alpha subunits had identical N-termini which were significantly homologous to the alpha subunit of the human adhesion platelet glycoprotein IIb/IIIa.
摘要
Mo1和gp160-gp93是分别存在于源自人类和豚鼠的粒细胞和单核细胞上的两种表面膜糖蛋白异二聚体。我们纯化了这两种抗原，发现它们的α亚基具有相同的N端，且与人血小板黏附糖蛋白IIb/IIIa的α亚基具有显著的同源性。
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