巴勒斯坦绝经期骨质疏松症妇女对阿伦膦酸盐治疗的认知和依从性。
Knowledge and compliance towards alendronate therapy among postmenopausal women with osteoporosis in Palestine.
机构信息
Department of Pharmacy, College of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus, Palestine.
出版信息
BMC Womens Health. 2022 Apr 7;22(1):105. doi: 10.1186/s12905-022-01690-5.
BACKGROUND
Postmenopausal women compliance to alendronate therapy is suboptimal due to the complex dosing requirements. The poor compliance may increase their potential of fractures and the prevalence of side effects. In this study, the compliance of osteoporotic women on bisphosphonate therapy to the complex dosing instructions and their knowledge of alendronate-interactions were assessed.
METHODS
This is a cross-sectional study, using self-administered questionnaire involving 224 osteoporotic women on alendronate therapy, who visited the orthopedic clinics and community pharmacies in the West Bank. Data was collected using a validated questionnaire consisting of 4 sections and analyzed by descriptive statistics. Moreover, associations between patient's socio-demographic characteristics and the extent of compliance and knowledge of alendronate interactions are established in this study.
RESULTS
A total of 300 questionnaires were distributed and 224 were completed. The median compliance score to alendronate dosing instructions was 5 out of a possible maximum 7, and the median knowledge score about alendronate interactions was 7 out of a possible maximum 14. Factors found to affect either or both the knowledge and compliance to alendronate dosing instructions were, residency, and the source of instructions.
CONCLUSION
This study identified the importance of compliance and knowledge gaps among postmenopausal women treated with alendronate. Therefore, appropriate knowledge about the importance of proper compliance to dosing instructions and avoidance of interactions is of a great benefit for maximizing clinical effectiveness, lowering fracture risk and prevention of adverse effects of alendronate among patients treated with alendronate in Palestine.
背景
由于复杂的剂量要求，绝经后妇女对阿伦膦酸盐治疗的依从性并不理想。较差的依从性可能会增加她们骨折的风险和副作用的发生率。在这项研究中，评估了骨质疏松症妇女对双膦酸盐治疗的依从性与复杂剂量说明的依从性，以及她们对阿仑膦酸钠相互作用的了解程度。
方法
这是一项横断面研究，使用自我管理问卷，涉及在西岸骨科诊所和社区药房接受阿伦膦酸盐治疗的 224 名骨质疏松症妇女。使用经过验证的问卷收集数据，问卷包括 4 个部分，并进行描述性统计分析。此外，本研究还确定了患者社会人口统计学特征与阿仑膦酸钠相互作用的依从性和知识程度之间的关联。
结果
共发放 300 份问卷，完成 224 份。阿仑膦酸钠剂量说明依从性的中位数评分为 7 分满分中的 5 分，阿仑膦酸钠相互作用知识评分的中位数为 14 分满分中的 7 分。影响阿仑膦酸钠剂量说明的依从性和知识的因素包括居住地和来源。
结论
本研究确定了接受阿伦膦酸钠治疗的绝经后妇女在依从性和知识差距方面的重要性。因此，适当了解正确依从剂量说明和避免相互作用的重要性，对于最大限度地提高临床疗效、降低骨折风险以及预防巴勒斯坦接受阿伦膦酸钠治疗的患者的不良反应具有重要意义。
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