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In pediatric rheumatologic disease, methotrexate leads to mildly changed bloodwork on the second day after administration.

作者信息

Hugle Boris, Fischer Nadine, Haas Johannes-Peter

机构信息

German Center for Pediatric Rheumatology, Garmisch-Partenkirchen, Gehfeldstrasse 24, 82467, Garmisch-Partenkirchen, Bavaria, Germany.

出版信息

Pediatr Rheumatol Online J. 2022 Apr 7;20(1):23. doi: 10.1186/s12969-022-00685-8.

DOI:10.1186/s12969-022-00685-8
PMID:35392929
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8991882/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e78d/8991882/2c07dc02a77c/12969_2022_685_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e78d/8991882/2c07dc02a77c/12969_2022_685_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e78d/8991882/2c07dc02a77c/12969_2022_685_Fig1_HTML.jpg

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1
In pediatric rheumatologic disease, methotrexate leads to mildly changed bloodwork on the second day after administration.在儿童风湿性疾病中,甲氨蝶呤在给药后第二天会导致血液检查结果出现轻微变化。
Pediatr Rheumatol Online J. 2022 Apr 7;20(1):23. doi: 10.1186/s12969-022-00685-8.
2
[Chinese expert-based consensus for methotrexate in rheumatic diseases].[中国风湿性疾病甲氨蝶呤专家共识]
Zhonghua Nei Ke Za Zhi. 2018 Oct 1;57(10):719-722. doi: 10.3760/cma.j.issn.0578-1426.2018.10.005.
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[Methotrexate in rheumatology].[甲氨蝶呤在风湿病学中的应用]
Rev Rhum Ed Fr. 1993 Jul-Sep;60(7-8):481-4.
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The rational use of methotrexate in rheumatoid arthritis and other rheumatic diseases.甲氨蝶呤在类风湿关节炎及其他风湿性疾病中的合理应用。
Br J Rheumatol. 1997 Nov;36(11):1196-204. doi: 10.1093/rheumatology/36.11.1196.
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Methotrexate.甲氨蝶呤
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Methotrexate: mechanism of action, pharmacokinetics, clinical indications, and toxicity.
Curr Opin Rheumatol. 1991 Jun;3(3):363-8.
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Methotrexate is the leading DMARD in Finland.甲氨蝶呤是芬兰主要的缓解病情抗风湿药。
Ann Rheum Dis. 2003 May;62(5):494; author reply 494-5. doi: 10.1136/ard.62.5.494.
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[General principles of immunosuppressive therapy of diseases of rheumatic origin].[风湿性疾病免疫抑制治疗的一般原则]
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Methotrexate: its use in the rheumatic diseases.
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本文引用的文献

1
2019 American College of Rheumatology/Arthritis Foundation Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Non-Systemic Polyarthritis, Sacroiliitis, and Enthesitis.2019 年美国风湿病学会/关节炎基金会治疗幼年特发性关节炎指南:非系统性多关节炎、骶髂关节炎和附着点炎的治疗方法。
Arthritis Care Res (Hoboken). 2019 Jun;71(6):717-734. doi: 10.1002/acr.23870. Epub 2019 Apr 25.
2
Methotrexate in juvenile idiopathic arthritis: advice and recommendations from the MARAJIA expert consensus meeting.甲氨蝶呤用于青少年特发性关节炎:MARAJIA专家共识会议的建议与推荐
Pediatr Rheumatol Online J. 2018 Jul 11;16(1):46. doi: 10.1186/s12969-018-0255-8.
3
Measuring transaminases in patients with rheumatoid arthritis on weekly methotrexate: does timing of blood testing matter?
对每周服用甲氨蝶呤的类风湿关节炎患者进行转氨酶检测:采血时间重要吗?
Clin Rheumatol. 2016 Dec;35(12):3053-3056. doi: 10.1007/s10067-016-3361-3. Epub 2016 Jul 29.
4
[Evidence-based use of methotrexate in children with rheumatic disorders. Consensus statement of the Working Group for Children and Adolescents with Rheumatic Diseases in Germany (AGKJR) and the Working Group Pediatric Rheumatology Austria].[甲氨蝶呤在风湿性疾病患儿中的循证应用。德国儿童和青少年风湿病工作组(AGKJR)及奥地利儿童风湿病工作组的共识声明]
Z Rheumatol. 2004 Apr;63(2):147-58. doi: 10.1007/s00393-004-0534-2.
5
Pharmacokinetics of subcutaneous methotrexate.
J Clin Oncol. 1988 Dec;6(12):1882-6. doi: 10.1200/JCO.1988.6.12.1882.