海曼肾炎中的单克隆自身抗体。
Monoclonal autoantibodies in Heymann nephritis.
作者信息
Kimura S, Sakurai A, Morioka T, Matsui K, Nakamura T, Yakata M, Oite T, Shimizu F
出版信息
Clin Exp Immunol. 1986 Jul;65(1):28-33.
We have developed hybridoma cell lines, each of which secretes a monoclonal antibody (MoAb) to rat renal and hepatic tissue antigens, from Lewis rat with Heymann's nephritis. Three antibodies bind to the brush border of proximal tubular epithelium (BB), one in a fine net-like pattern (no. 3-11), another one in a coarse granular pattern (no. 1-8) and the third one in a typical pattern (no. 3-9). Three antibodies bind to glomerulus in characteristic patterns but not to BB. After repeated intravenous injections of MoAb (no. 3-11), granular mesangial deposits of rat IgG were observed and of MoAb (no. 1-8), fine granular deposition along capillary walls. These monoclonal autoantibodies should be of value in research on the mechanism of autoimmune membranous nephropathy.
我们从患有海曼肾炎的刘易斯大鼠中开发出了杂交瘤细胞系，每个细胞系都分泌一种针对大鼠肾和肝组织抗原的单克隆抗体（MoAb）。三种抗体与近端肾小管上皮的刷状缘（BB）结合，一种呈细网状模式（编号3 - 11），另一种呈粗颗粒状模式（编号1 - 8），第三种呈典型模式（编号3 - 9）。三种抗体以特征性模式与肾小球结合，但不与BB结合。在反复静脉注射单克隆抗体（编号3 - 11）后，观察到大鼠IgG的颗粒状系膜沉积，而注射单克隆抗体（编号1 - 8）后，沿毛细血管壁有细颗粒状沉积。这些单克隆自身抗体在自身免疫性膜性肾病的机制研究中应具有价值。
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