Martin J N, Martin R W, Morrison J C
Clin Perinatol. 1986 Dec;13(4):853-68.
Vaso-occlusive sickle cell crisis (VSCC) is the most common maternal complication in pregnancies associated with sickle hemoglobinopathies. Maternal and fetal morbidity and mortality secondary to this serious obstetric problem can be reduced significantly with a well-devised therapeutic plan, expert perinatal teams, and careful attention to obstetric and medical detail in a setting of comprehensive tertiary health care. A variety of better medical, obstetric, and neonatal care practices have helped considerably to improve the combined life span for affected mothers and fetuses. In the absence of any effective and safe pharmacologic agent to prevent sickle crisis, our experience suggests that adherence to the described management principles offers the greatest hope to the sickling parturient that her vaso-occlusive crises can be effectively managed for a healthy outcome, both for herself and for her baby.
血管闭塞性镰状细胞危象（VSCC）是与镰状血红蛋白病相关妊娠中最常见的母体并发症。通过精心设计的治疗方案、专业的围产期团队以及在全面的三级医疗保健环境中对产科和医疗细节的密切关注，可显著降低这一严重产科问题导致的母婴发病率和死亡率。各种更好的医疗、产科和新生儿护理措施极大地有助于延长受影响母亲和胎儿的综合寿命。在缺乏任何有效且安全的预防镰状细胞危象的药物的情况下，我们的经验表明，遵循所述的管理原则为患有镰状细胞病的产妇提供了最大的希望，即她的血管闭塞性危象能够得到有效管理，从而为她自己和她的宝宝带来健康的结果。
