Ma Xiaohua, Yang Bo, Li Xiaojing, Miao Zhigang
Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215123, China.
Institute of Neuroscience of Soochow University, 199 Ren-Ai Road, Suzhou, 215123, China.
Neurotox Res. 2022 Jun;40(3):884-891. doi: 10.1007/s12640-022-00505-7. Epub 2022 Apr 8.
5-Hydroxymethylcytosine (5hmC) has recently been found that plays an important role in many diseases; however, there are still few studies in the field of stroke. The purpose of this review is to introduce the influence and function of 5hmC in stroke, in order for more people can study it. In this review, we introduced the role of 5hmC in ischemia and hemorrhage stroke, and summarized the possible therapeutic prospects of 5hmC in stroke. In conclusion, we suggest that 5hmC may serve as a biomarker or therapeutic target for the treatment of stroke.
5-羟甲基胞嘧啶（5hmC）最近被发现在许多疾病中发挥重要作用；然而，在中风领域的研究仍然很少。本综述的目的是介绍5hmC在中风中的影响和功能，以便更多的人能够对其进行研究。在本综述中，我们介绍了5hmC在缺血性和出血性中风中的作用，并总结了5hmC在中风中可能的治疗前景。总之，我们认为5hmC可能作为中风治疗的生物标志物或治疗靶点。
