Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia; Department of Chemistry, Faculty of Science and Technology, Al-Neelain University, Khartoum, Sudan.
Profiles Drug Subst Excip Relat Methodol. 2022;47:1-54. doi: 10.1016/bs.podrm.2021.10.001. Epub 2021 Dec 30.
Vinpocetine (VIN) is a herbal supplement extracted from the periwinkle plant. It is a multi-action agent, which is used to treat various neurological disorders such as Alzheimer's and Parkinson's disease. Vinpocetine has also anti-inflammatory, analgesic, antioxidant property and treats various thinking and memory problems. Currently, vinpocetine is also available in the market as a dietary supplement to enhance cognition and memory. This profile explains the physicochemical properties, methods of preparation, content of related impurities and different spectroscopical behavior of vinpocetine. It also discusses the reported methods of analysis of the drug, which include Compendial Methods, Electrochemical Methods, Spectrophotometric Methods and Chromatographic Methods of analysis. Furthermore, this profile explains the stability of the drug subjected to stress conditions of acid, alkaline and photolytic degradation. In addition, the clinical applications of the drug, its uses, side effects, dosing information, pharmacokinetics and mechanism of action are also discussed.
长春西汀（VIN）是从长春花植物中提取的草药补充剂。它是一种多作用剂，用于治疗各种神经紊乱，如阿尔茨海默病和帕金森病。长春西汀还具有抗炎、镇痛、抗氧化特性，并可治疗各种思维和记忆问题。目前，长春西汀也作为膳食补充剂在市场上销售，以增强认知和记忆。本专题介绍了长春西汀的理化性质、制备方法、相关杂质的含量以及不同的光谱行为。还讨论了该药物的分析方法，包括法定方法、电化学方法、分光光度法和色谱法。此外，本专题还解释了药物在酸、碱和光降解等应激条件下的稳定性。此外，还讨论了该药物的临床应用、用途、副作用、剂量信息、药代动力学和作用机制。
