Aström M, Edhag O, Nyquist O, Vallin H
Eur Heart J. 1986 Nov;7(11):931-6. doi: 10.1093/oxfordjournals.eurheartj.a061997.
There are few placebo controlled studies in acute myocardial infarction concerning the haemodynamic effects of beta blockade. In a controlled, double-blind randomized study, the haemodynamic effects of sotalol were evaluated in 20 patients with acute myocardial infarction within 24 hours of the onset. Sotalol was administered to 10 patients over 12 hours by a continuous infusion including three different infusion rates. A serum level around 1.4 microgram ml-1 was achieved after one hour of infusion. The placebo patients were given saline infusion. The patients were monitored invasively using a thermodilution catheter in the pulmonary artery. In the sotalol group, there was a significant reduction in heart rate, systolic blood pressure, cardiac output and stroke volume compared to placebo. A slight increase in the mean pressures of right atrium, pulmonary artery systolic and diastolic pressures was also seen. The infusion was well tolerated and no adverse reaction was seen.
关于β受体阻滞剂对急性心肌梗死血流动力学影响的安慰剂对照研究较少。在一项对照、双盲随机研究中，对20例急性心肌梗死发病24小时内的患者评估了索他洛尔的血流动力学效应。10例患者通过持续输注12小时给予索他洛尔，包括三种不同的输注速率。输注1小时后血清水平达到约1.4微克/毫升。安慰剂组患者给予生理盐水输注。使用肺动脉热稀释导管对患者进行有创监测。与安慰剂相比，索他洛尔组的心率、收缩压、心输出量和每搏输出量显著降低。右心房平均压力、肺动脉收缩压和舒张压也略有升高。输注耐受性良好，未观察到不良反应。
