Department of Human-Computer Interaction, Hanyang University, Ansan, Republic of Korea.
Department of Psychiatry, Samsung Medical Center, Seoul, Republic of Korea.
Sci Rep. 2022 Apr 8;12(1):5920. doi: 10.1038/s41598-022-10038-w.
Studies comparing bipolar disorder (BD) and major depressive disorder (MDD) are scarce, and the neuropathology of these disorders is poorly understood. This study investigated source-level cortical functional networks using resting-state electroencephalography (EEG) in patients with BD and MDD. EEG was recorded in 35 patients with BD, 39 patients with MDD, and 42 healthy controls (HCs). Graph theory-based source-level weighted functional networks were assessed via strength, clustering coefficient (CC), and path length (PL) in six frequency bands. At the global level, patients with BD and MDD showed higher strength and CC, and lower PL in the high beta band, compared to HCs. At the nodal level, compared to HCs, patients with BD showed higher high beta band nodal CCs in the right precuneus, left isthmus cingulate, bilateral paracentral, and left superior frontal; however, patients with MDD showed higher nodal CC only in the right precuneus compared to HCs. Although both MDD and BD patients had similar global level network changes, they had different nodal level network changes compared to HCs. Our findings might suggest more altered cortical functional network in patients with BD than in those with MDD.
比较双相情感障碍（BD）和重度抑郁症（MDD）的研究很少，这些疾病的神经病理学知之甚少。本研究使用静息态脑电图（EEG）研究了 BD 和 MDD 患者的皮质源功能网络。对 35 名 BD 患者、39 名 MDD 患者和 42 名健康对照者（HCs）进行了 EEG 记录。通过在六个频带中评估基于图论的源水平加权功能网络的强度、聚类系数（CC）和路径长度（PL）。在全局水平上，与 HCs 相比，BD 和 MDD 患者在高频带中表现出更高的强度和 CC，以及更低的 PL。在节点水平上，与 HCs 相比，BD 患者右侧楔前叶、左侧扣带前回、双侧旁中央和左侧额上回的高β波段节点 CC 较高；而 MDD 患者只有右侧楔前叶的节点 CC 高于 HCs。尽管 MDD 和 BD 患者的整体网络变化相似，但与 HCs 相比，它们的节点水平网络变化不同。我们的研究结果可能表明，BD 患者的皮质功能网络改变较 MDD 患者更为明显。
