一项关于高分辨率全结肠腔内测压和结肠传输试验在中国人功能性便秘诊断中的应用的描述性研究。

A descriptive study of high resolution total colonic intracavitary manometry and colonic transit test in the diagnostic efficacy of functional constipation in Chinese patients.

机构信息

Department of Pathology, Tianjin Medical University General Hospital, Tianjin, 300052, People's Republic of China.

Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, 300121, People's Republic of China.

出版信息

BMC Gastroenterol. 2022 Apr 9;22(1):175. doi: 10.1186/s12876-022-02240-x.

BACKGROUND

This study was to observe the diagnostic efficacy of high resolution total colonic intracavitary manometry (HRCM) vs colonic transit test (CTT) in the assessment of functional constipation (FC) in Chinese patients.

METHODS

Seventy-nine cases of patients with severe FC who were admitted and received colon resection between July 2016 and July 2019 at the Tianjin Union Medical Center were retrospectively reviewed. Before operation, all patients received CTT at outpatient service, followed by HRCM at ward. The resected tissues were subject to histological observation, which was used to determine the diagnostic efficacy of HRCM vs CTT.

RESULTS

The accuracy of CTT for the FC diagnosis was 69.6% (55/79), and the false negative ratio was 30.4%. The accuracy of HRCM for the FC diagnosis was 81.0% (64/79), and the false negative ratio was 19.0% (15/79). Twelve patients showed normal characteristics after CTT but abnormal after HRCM. In contrast, only 4 showed normal after HRCM but abnormal after CTT. In addition, among the 79 patients 12 were detected normal by both CTT and HRCM.

CONCLUSION

HRCM can be more suitable to assess FC compared with CTT, while CTT is still indispensable for HRCM to diagnose FC.

背景

本研究旨在观察高分辨率全结肠腔内测压（HRCM）与结肠通过时间试验（CTT）在评估中国功能性便秘（FC）患者中的诊断效能。

方法

回顾性分析 2016 年 7 月至 2019 年 7 月期间在天津医科大学总医院就诊并行结肠切除术的 79 例重度 FC 患者。所有患者在门诊行 CTT 检查，随后在病房行 HRCM 检查。切除的组织进行组织学观察，以确定 HRCM 与 CTT 的诊断效能。

结果

CTT 对 FC 的诊断准确性为 69.6%（55/79），假阴性率为 30.4%。HRCM 对 FC 的诊断准确性为 81.0%（64/79），假阴性率为 19.0%（15/79）。12 例患者 CTT 表现正常但 HRCM 异常，而仅有 4 例 HRCM 正常但 CTT 异常。此外，79 例患者中有 12 例 CTT 和 HRCM 均正常。