I型重度支气管肺发育不良婴儿的肺血管疾病与呼吸改善之间的关联。
The association between pulmonary vascular disease and respiratory improvement in infants with type I severe bronchopulmonary dysplasia.
作者信息
Carpenter Ryan J, Srdanovic Nina, Rychlik Karen, Sen Shawn K, Porta Nicolas F M, Hamvas Aaron E, Murthy Karna, Hauck Amanda L
机构信息
Ann & Robert H. Lurie Children's Hospital of Chicago and the Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Biostatistics Collaboration Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
出版信息
J Perinatol. 2022 Jun;42(6):788-795. doi: 10.1038/s41372-022-01386-6. Epub 2022 Apr 9.
OBJECTIVE
To describe the association between echocardiographic measures of pulmonary vascular disease and time to respiratory improvement among infants with Type I severe bronchopulmonary dysplasia (sBPD).
STUDY DESIGN
We measured the pulmonary artery acceleration time indexed to the right ventricular ejection time (PAAT/RVET) and right ventricular free wall longitudinal strain (RVFWLS) at 34-41 weeks' postmenstrual age. Cox-proportional hazards models were used to estimate the relationship between the PAAT/RVET, RVFWLS, and the outcome: days from 36 weeks' postmenstrual age to room-air or discharge with oxygen (≤0.5 L/min).
RESULT
For 102 infants, the mean PAAT/RVET and RVFWLS were 0.27 ± 0.06 and -22.63 ± 4.23%. An abnormal measurement was associated with an increased time to achieve the outcome (PAAT/RVET: 51v24, p < 0.0001; RVFWLS; 62v38, p = 0.0006). A normal PAAT/RVET was independently associated with a shorter time to outcome (aHR = 2.04, 1.11-3.76, p = 0.02).
CONCLUSION
The PAAT/RVET may aid in anticipating timing of discharge in patients with type I severe BPD.
目的
描述I型重度支气管肺发育不良（sBPD）婴儿的肺血管疾病超声心动图测量值与呼吸改善时间之间的关联。
研究设计
我们在孕龄34 - 41周时测量了肺动脉加速时间与右心室射血时间的比值（PAAT/RVET）以及右心室游离壁纵向应变（RVFWLS）。采用Cox比例风险模型来估计PAAT/RVET、RVFWLS与以下结局之间的关系：从孕龄36周起至空气氧疗或出院时吸氧（≤0.5 L/min）的天数。
结果
对于102例婴儿，平均PAAT/RVET和RVFWLS分别为0.27±0.06和 - 22.63±4.23%。测量值异常与达到该结局的时间增加相关（PAAT/RVET：51对24，p < 0.0001；RVFWLS：62对38，p = 0.0006）。正常的PAAT/RVET与较短的达到结局时间独立相关（校正风险比 = 2.04，1.11 - 3.76，p = 0.02）。
结论
PAAT/RVET可能有助于预测I型重度BPD患者的出院时间。
Zotero 插件