Cascone Tina, Chelvanambi Manoj, Wargo Jennifer A
Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Trends Immunol. 2022 May;43(5):337-339. doi: 10.1016/j.it.2022.03.007. Epub 2022 Apr 6.
Gut microbes can shape cancer immunotherapy responses; however, specific taxa have not been tested prospectively as biomarkers. Derosa and colleagues now demonstrate that the presence of Akkermansia muciniphila in baseline stool samples can be associated with improved outcomes and enhanced antitumor immune cell infiltrates in patients with lung cancer treated with immune checkpoint blockade (ICB).
肠道微生物可影响癌症免疫治疗反应；然而，尚未对特定的微生物分类群作为生物标志物进行前瞻性测试。德罗萨及其同事现在证明，在接受免疫检查点阻断（ICB）治疗的肺癌患者中，基线粪便样本中存在嗜黏蛋白阿克曼氏菌可能与更好的治疗结果及增强的抗肿瘤免疫细胞浸润有关。
